105143-07-5Relevant articles and documents
From aldehydes to nitriles, a general and high yielding transformation using HOF·CH3CN complex
Carmeli, Mira,Shefer, Neta,Rozen, Shlomo
, p. 8969 - 8972 (2006)
N,N-Dimethylhydrazones of aldehydes undergo a rapid oxidative cleavage to form nitriles in very high yields on reaction with HOF·CH3CN under mild conditions. The reaction is chemoselective and proceeds rapidly without racemization. The nitriles were resistant to further oxidation, even when a large excess of the reagent was employed.
Improved efficient conversion of aldehydes to nitriles via their N,N- dimethyl hydrazones
Kamal, Ahmed,Arifuddin,Venugopal Rao
, p. 4507 - 4512 (2007/10/03)
Aldehyde N,N-dimethylhydrazones undergoes facile oxidative cleavage to nitriles on reaction with DMS and K2CO3 in quantitative yields. Nitriles can also be easily obtained in high yields in a 'one-pot' process starting from the corresponding aldehydes.