1051487-82-1 Usage
Description
(±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 3R and 4S positions, as well as the presence of an oxo group and a phenyl ring. (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide also features a hydrazide group and a bromophenylethylidene moiety, which may contribute to its potential biological activity and applications.
Uses
Used in Pharmaceutical Research:
(±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide is used as a selective protease-activated receptor 2 (PAR-2) agonist for investigating the physiological roles of PAR-2 receptors. (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylicacid2-[1-(3-bromophenyl)ethylidene]hydrazide can be employed in various experimental settings to study the effects of PAR-2 activation on cellular processes and signaling pathways.
Used in Drug Development:
Due to its selective agonist activity, (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide may have potential applications in the development of new drugs targeting PAR-2 receptors. This could lead to the discovery of novel therapeutic agents for treating various diseases and conditions where PAR-2 receptor modulation is implicated.
Used in Chemical Synthesis:
The unique structure of (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide may also be of interest to researchers in the field of organic chemistry. It could serve as a starting material or intermediate in the synthesis of other complex organic compounds with potential applications in various industries, such as pharmaceuticals, materials science, or agrochemicals.
Biological Activity
ac 264613 is a potent agonist of par2 with pec50 value of 7.5 and potencies range from 30 to 100 nm [1, 2].protease-activated receptor 2 (par2) also known as coagulation factor ii (thrombin) receptor-like 1 (f2rl1) or g-protein coupled receptor 11 (gpr11) is expressed in vascular tissue and highly vascular organs and involves in the vascular tone regulation. it has been shown that par2 plays a pivotal role in vessel inflammation and wound healing processes [2].ac 264613 is a selective par2 agonist and has no effect on other pars. when tested with hek 293 t cells (par2 wild type) and knrk cells (transfected with human par2 receptors) for stimulates pi hydrolysis and ca2+ mobilization assays, ac 264613 showed effect with pec50 value of 6.9 and 7.0,respectively [1]. using quickchange mutagenesis manner, nih 3t3 cells were made with ecl2 mutations in q233e, e232r, e232r/q233r, f240s, and f240s/s37p receptors and ac 264613 treatment par2 f240s receptors were constitutively expressed in multiple functional endpoints while had no effect on e232 and q233 mutaions [2].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 264613 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1].
references
[1]. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808. [2]. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.
Check Digit Verification of cas no
The CAS Registry Mumber 1051487-82-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,1,4,8 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1051487-82:
(9*1)+(8*0)+(7*5)+(6*1)+(5*4)+(4*8)+(3*7)+(2*8)+(1*2)=141
141 % 10 = 1
So 1051487-82-1 is a valid CAS Registry Number.
