105186-33-2

Basic information

• Product Name: Tibolone 3-Dimethyl Ketal
• Synonyms: Tibolone 3-Dimethyl Ketal;(7alpha,17alpha)-3,3-Dimethoxy-7-methyl-19-norpregn-5(10)-en-20-yn-17-ol;(7a,17a)-17-Hydroxy-7-methyl-3,3-dimethoxy-19-NorPregn-5(10)-20-yn
• CAS NO: 105186-33-2
• Molecular Formula: C₂₃H₃₄O₃
• Molecular Weight: 358.51426
• Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 105186-33-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: Tibolone 3-Dimethyl Ketal(CAS DataBase Reference)
• NIST Chemistry Reference: Tibolone 3-Dimethyl Ketal(105186-33-2)
• EPA Substance Registry System: Tibolone 3-Dimethyl Ketal(105186-33-2)

Safety Data

• Hazardous Substances Data: 105186-33-2(Hazardous Substances Data)

Usage

Uses

Tibolone intermediate.

Upstream product

• 67-56-1 methanol 
• 1162-60-3 7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one 
• 63841-74-7 7α-methyl-3,17-dioxoandrost-4-en-19-al 
• 105186-32-1 7α-methylestr-5(10)-ene-3,17-dione 
• 88247-84-1 3,3-dimethoxy-7α-methylestr-5(10)-en-17-one 
• 74-86-2 acetylene 

Downstream Products

• 5630-53-5 tibolone 
• 105186-34-3 10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one 
• 105186-35-4 10β,17β-dihydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one 
• 1162-60-3 7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one 

Relevant articles and documents

Preparation method of tibolone

The invention discloses a preparation method of tibolone, and belongs to the technical field of preparation and processing of steroid hormone drugs. According to the method, 6,7-didehydronorethindroneis used as an initial raw material, and tibolone is prepared through Grignard reaction, dietherification reaction and hydrolysis reaction. The 7-methyl introduction step is included in the Grignard reaction step in the synthesis route, so that special protection on 17-site hydroxyl is avoided, and the ratio of the 7-alpha methyl intermediate to the 7-beta methyl isomer obtained through the reaction is larger than 20:1; therefore, the single 7-alpha methyl intermediate can be obtained through simple treatment without chromatographic separation, the purification process is simple, and the purity of the final product reaches 99.0% or above, and the yield is higher than 60%; the raw materials are cheap and easily available, the reaction steps are few, the reaction conditions are mild and safe, and the control operation is easy; in addition, reagents used in the reaction are low in environmental pollution, and good economic and social benefits are achieved.