105202-37-7

Basic information

• Product Name: 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 105202-37-7
• Molecular Weight: 230.266
• Mol File: 105202-37-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione(105202-37-7)
• EPA Substance Registry System: 1,3-dimethyl-6-o-tolylpyrimidine-2,4(1H,3H)-dione(105202-37-7)

Safety Data

• Hazardous Substances Data: 105202-37-7(Hazardous Substances Data)

Upstream product

• 874-14-6 1,3-dimethyluracil 
• 95-46-5 2-methylphenyl bromide 
• 615-37-2 ortho-methylphenyl iodide 
• 108-88-3 toluene 
• 3013-92-1 1,3-dimethyl-5-fluorouracil 
• 31217-00-2 5-chloro-1,3-dimethyluracil 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 7033-39-8 5-bromo-1,3-dimethyluracil 

Relevant articles and documents

Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C-H bond activation

A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C-H bond activation for arylation. A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives.

Switching the regioselectivity of direct C-H arylation of 1,3-Dimethyluracil

An interesting dichotomy in the regioselectivity and mechanism of direct C-H arylation of 1,3-dimethyluracil was observed. Its Pd-catalyzed reactions with diverse aryl halides in the absence of Cui lead preferentially to 5-aryluracils, while reactions in

Synthesis of cyclooctapyrimidine-2,4-diones by photocycloaddition of 6-chloro-1,3-dimethyluracil to benzenes in the presence of trifluoroacetic acid

Photoreaction of 6-chloro-1,3-dimethyluracil in benzene and monosubstituted benzenes furnished cycloaddition products, cyclooctapyrimidine-2,4-dione derivatives, in the presence of trifluoroacetic acid.