105210-96-6Relevant articles and documents
Synthesis of (+)- and (-)-Homononactic Acid from (S)-1,2-Epoxybutane. Total Synthesis of Tetranactin by 'Reverse Coupe du Roi'
Schmidt, Ulrich,Werner, Juergen
, p. 996 - 998 (2007/10/02)
The synthesis of (+)- and (-)-homononactic acid was achieved in 6 steps and 4 steps respectively starting with the raction of 2-lithium-5-vinylfuran and (S)-(-)-1,2-epoxybutane; both enantiomers were used in the construction of the achiral macrolide antibiotic tetranactin by esterification and subsequent lactonisation with the thiolester of 3-cyano-4,6-dimethyl-2-thiopyridone.