1052138-94-9

Basic information

• Product Name: 2-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
• Synonyms: 2-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(Methylsulfonyl)pyridine-5-boronic acid pinacol ester;6-(Methylsulfonyl)pyridine-3-boronic Acid Pinacol Ester
• CAS NO: 1052138-94-9
• Molecular Formula: C₁₂H₁₈BNO₄S
• Molecular Weight: 301.1669
• EINECS: -0
• Mol File: 1052138-94-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 441.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.65±0.24(Predicted)
• CAS DataBase Reference: 2-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(1052138-94-9)
• EPA Substance Registry System: 2-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(1052138-94-9)

Safety Data

• Hazardous Substances Data: 1052138-94-9(Hazardous Substances Data)

Usage

General Description

2-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, also known as Methylsulfonyl pyridine boronic ester, is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It is a pyridine derivative with a boronic ester and a methylsulfonyl group attached to it, making it a versatile building block for creating complex organic molecules. The boronic ester functionality allows for the compound to be used in Suzuki-Miyaura cross-coupling reactions, a popular tool in organic synthesis. The methylsulfonyl group enhances the compound's stability and solubility in organic solvents, making it an ideal reagent for a wide range of chemical reactions. As a result, this chemical has found applications in the development of pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 98626-95-0 5-bromo-2-(methylsulfonyl)pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 51933-78-9 5-bromo-2-(methylsulfanyl)pyridine 
• 123-91-1 1,4-dioxane 

Downstream Products

• 1416000-08-2 2-(6-(methylsulfonyl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one 
• 1052138-97-2 {3-[4-(6-methanesulfonylpyridin-3-yl)phenoxy]propyl}carbamic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS

The present invention is directed to tricyclic compounds of the formula (I), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF

The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.