10522-42-6

Basic information

• Product Name: 8-Quinolinol, 4-methylbenzenesulfonate (ester)
• CAS NO: 10522-42-6
• Molecular Formula: C16H13NO3S
• Molecular Weight: 299.35
• Mol File: 10522-42-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 8-Quinolinol, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Quinolinol, 4-methylbenzenesulfonate (ester)(10522-42-6)
• EPA Substance Registry System: 8-Quinolinol, 4-methylbenzenesulfonate (ester)(10522-42-6)

Safety Data

• Hazardous Substances Data: 10522-42-6(Hazardous Substances Data)

Upstream product

• 148-24-3 8-quinolinol 
• 72973-25-2 N,N-dimethyl-1-(p-tolylsulfonyl)pyridin-1-ium-4-amine chloride 
• 4124-41-8 p-toluenesulfonylanhydride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1253596-50-7 diphenyl(quinolin-8-yl)phosphine oxide 
• 1006-47-9 iodo-8 quinoleine 
• 605-04-9 8-phenylquinoline 
• 578-66-5 8-amino quinoline 
• 35509-27-4 quinoline-8-carbonitrile 
• 57479-13-7 8-(4-methylphenyl)-quinoline 
• 1048028-28-9 3-quinolin-8-ylmethyl-benzoic acid ethyl ester 
• 57479-11-5 (±)-8-(o-tolyl)quinoline 
• 57479-35-3 8-(4-methoxyphenyl)quinoline 

Relevant articles and documents

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors.

Solvent-Free Synthesis of Aryl Tosylates under Microwave Activation

Synthesis of aryl tosylates from phenols requires only several minutes when conducted with controlled microwave heating under solvent-free condition. Eight different aryl tosylates were synthesized and isolated in good yields.

Coupling of C(sp3)-H bonds with C(sp2)-O electrophiles: mild, general and selective

Herein is reported the mild and general coupling of amine/ether C(sp3)-H bonds with various kinds of C(sp2)-O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification.

Iodine-induced synthesis of sulfonate esters from sodium sulfinates and phenols under mild conditions

An iodine-induced synthesis of sulfonate esters via cross-coupling reactions of sodium sulfinates with phenols is reported. This synthetic route is low-cost, facile, green and efficient, and could afford the target products with good to excellent yields u