1053228-28-6

Basic information

• Product Name: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-;EOS-60657
• CAS NO: 1053228-28-6
• Molecular Formula: C₆H₂Cl₃N₃
• Molecular Weight: 222.45918
• EINECS: 200-589-5
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 1053228-28-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.792 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine(1053228-28-6)
• EPA Substance Registry System: 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine(1053228-28-6)

Safety Data

• Hazardous Substances Data: 1053228-28-6(Hazardous Substances Data)

Usage

General Description

2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine is a synthetic compound that belongs to the class of pyrrolopyrimidine derivatives. It is a heterocyclic organic compound containing three chlorine atoms and is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical has been identified as a potential mutagen and may exhibit toxic effects on aquatic organisms. It is important to handle this chemical with caution and to adhere to proper safety protocols when working with it in a laboratory or industrial setting.

Upstream product

• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 39929-79-8 pyrrolo<2,3-d>pyrimidin-2,4-dione 

Downstream Products

• 1053228-31-1 2,4,5-trichloro-7-[2-deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 1346448-07-4 2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide 
• 1346448-08-5 2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide 
• 1346448-09-6 2-((2-((5-amino-2-methoxyphenyl)amino)-5-chloro-7-((2-(trimethyl-silyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide 
• 1346448-10-9 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide 
• 1346448-11-0 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide 
• 1428776-29-7 5-chloro-N-(1-methyl-1H-pyrazol-4-yl)-4-(1-phenylethoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1428775-99-8 ((3,4-trans)-tert-butyl 3-((S)-1-((tert-butyldiphenylsilyl)oxy)ethyl)-4-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)pyrrolidine-1-carboxylate) 
• 1700693-08-8 [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinylmethanone 
• 1428774-45-1 1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one 

Relevant articles and documents

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d

PYRROLOPYRIMIDINE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2

Disclosed are compounds that possess inhibitory activity against LRRK2. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat neurodegenerative diseases and disorders such as Parkinson's disease and brain cancer (e.g., gliomas and glioblastomas).

COMPOUND, COMPOSITIONS, AND METHODS

Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.