10537-86-7

Basic information

• Product Name: 4-hydroxy-3,5-bis(isopropyl)benzaldehyde
• Synonyms: 4-hydroxy-3,5-bis(isopropyl)benzaldehyde;3,5-Diisopropyl-4-hydroxybenzaldehyde;4-Hydroxy-3,5-bis(1-methylethyl)benzaldehyde;Einecs 234-111-2;4-Hydroxy-3,5-diisopropylbenzaldehyde;Benzaldehyde,4-hydroxy-3,5-bis(1-Methylethyl)-;3,5-Bis(1-methylethyl)-4-hydroxybenzaldehyde
• CAS NO: 10537-86-7
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.28082
• EINECS: 234-111-2
• Mol File: 10537-86-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 119-120 °C
• Boiling Point: 291.5°C at 760 mmHg
• Flash Point: 122.6°C
• Appearance: /
• Density: 1.033g/cm³
• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Dichloromethane; Ethyl Acetate
• PKA: 8.83±0.23(Predicted)
• CAS DataBase Reference: 4-hydroxy-3,5-bis(isopropyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3,5-bis(isopropyl)benzaldehyde(10537-86-7)
• EPA Substance Registry System: 4-hydroxy-3,5-bis(isopropyl)benzaldehyde(10537-86-7)

Safety Data

• Hazardous Substances Data: 10537-86-7(Hazardous Substances Data)

Usage

Description

4-hydroxy-3,5-bis(1-methylethyl)-benzaldehyde is an organic compound that serves as a key intermediate in the synthesis of various chemical compounds and derivatives. It is characterized by the presence of a hydroxyl group and two isopropyl substituents attached to a benzene ring, with an aldehyde functional group.

Uses

Used in Chemical Synthesis:
4-hydroxy-3,5-bis(1-methylethyl)-benzaldehyde is used as a starting material for the one-pot synthesis of 3,5-Dialkyl-4-hydroxybenzonitrile derivatives. This synthesis process allows for the creation of a variety of chemical compounds with potential applications in various industries.
Used in the Synthesis of MTS PHOTO-SWITCHABLE Compound (M125115):
4-hydroxy-3,5-bis(1-methylethyl)-benzaldehyde is an intermediate used in the synthesis of MTS PHOTO-SWITCHABLE Compound (M125115), a derivative compound of Maleidopropionic Acid (M140750). 4-hydroxy-3,5-bis(isopropyl)benzaldehyde is a sulfhydryl reactive heterobifunctional crosslinking reagent, which has potential applications in the fields of biochemistry and materials science, particularly for the development of new materials with unique properties and functions.

InChI:InChI=1/C13H18O2/c1-8(2)11-5-10(7-14)6-12(9(3)4)13(11)15/h5-9,15H,1-4H3

Upstream product

• 104-93-8 p-methylanizole 
• 20766-99-8 2,6-Di-iso-propyl-4-methylphenol 
• 2078-54-8 2,6-diisopropylphenol 
• 76-05-1 trifluoroacetic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 2053-29-4 methyleneamine 
• 4885-02-3 Dichloromethyl methyl ether 
• 1336-21-6 ammonium hydroxide 
• 50-00-0 formaldehyd 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 20172-68-3 C₂₅H₄₃NO 
• 221445-27-8 3,5-diisopropyl-4-methoxybenzaldehyde 
• 180090-36-2 2-(3,5-diisopropyl-4-hydroxyphenyl)-3-(3-hydroxypropyl)-1,3-thiazolidin-4-one 
• 180090-52-2 2-(3,5-diisopropyl-4-hydroxyphenyl)-3-(3-chloropropyl)-1,3-thiazolidin-4-one 
• 515815-39-1 3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-{[imino(thien-2-yl)methyl]amino}benzyl)propanamide 
• 521098-14-6 3-(4-acetoxy-3,5-diisopropyl-phenyl)-propionic acid ethyl ester 
• 515815-38-0 3-(4-hydroxy-3,5-diisopropylphenyl)propanoic acid 
• 655245-46-8 acetic acid 5-{2-[2-(4-hydroxymethyl-2,6-diisopropyl-phenoxy)-ethoxy]-ethoxy}-naphthalen-1-yl ester 
• 655245-45-7 toluene-4-sulfonic acid 2-[2-(4-hydroxymethyl-2,6-diisopropyl-phenoxy)-ethoxy]-ethyl ester 

Relevant articles and documents

Efficient and flexible synthesis of new photoactivatable propofol analogs

Propofol is a widely used general anesthetic, which acts by binding to and modulating several neuronal ion channels. We describe the synthesis of photoactivatable propofol analogs functionalized with an alkyne handle for bioorthogonal chemistry. Such tools are useful for detecting and isolating photolabeled proteins. We designed expedient and flexible synthetic routes to three new diazirine-based crosslinkable propofol derivatives, two of which have alkyne handles. As a proof of principle, we show that these compounds activate heterologously expressed Transient Receptor Potential Ankyrin 1 (TRPA1), a key ion channel of the pain pathway, with a similar potency as propofol in fluorescence-based functional assays. This work demonstrates that installation of the crosslinkable and clickable group on a short nonpolar spacer at the para position of propofol does not affect TRPA1 activation, supporting the utility of these chemical tools in identifying and characterizing potentially druggable binding sites in propofol-interacting proteins.

2,6-diisopropylphenol compound as well as preparation method and application thereof

The invention relates to a 2,6-diisopropylphenol compound as well as a preparation method and application thereof. The invention particularly relates to a compound shown as a general formula (A) in the description, a preparation method and application of the compound in preparation of anesthetic drugs and drugs for treating cerebral arterial thrombosis. The compound shown in the formula A is characterized in that an olefinic bond in the formula is of a trans-structure; and R1 is selected from CH2OR2 and COOR3.

Preparation method VEGFR2 selective inhibitor SU1498

The preparation method comprises the following steps VEGFR2: firstly converting diisopropyl phenol to SU1498 hydroxyl - 3333, 5-diisopropylphenyl,propyl SU1498 acrylamide 2 - to obtain the target product) - N - (3 - and obtaining)-cyan- 3 3 3 3 3-diisopropyl phenyl- acrylamide: The preparation method disclosed by the invention is low in cost, easy to obtain :2,6 - and high 4 - purity . in total yield after simple 2 -process method. (E)- 2 - The preparation method disclosed by the invention is simple, and, easy to obtain, the, final product)-cyanacetic acid, and the preparation, method of.selectivity inhibitor, is shown in the present invention.