1053728-82-7

Basic information

• Product Name: (3aS,4S,6R,6aR)-2,2-Dimethyl-6-{6-[2-(1-pyridin-2-ylmethyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide
• Synonyms: (3aS,4S,6R,6aR)-2,2-Dimethyl-6-{6-[2-(1-pyridin-2-ylmethyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide
• CAS NO: 1053728-82-7
• Molecular Weight: 594.673
• Mol File: 1053728-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3aS,4S,6R,6aR)-2,2-Dimethyl-6-{6-[2-(1-pyridin-2-ylmethyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,4S,6R,6aR)-2,2-Dimethyl-6-{6-[2-(1-pyridin-2-ylmethyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide(1053728-82-7)
• EPA Substance Registry System: (3aS,4S,6R,6aR)-2,2-Dimethyl-6-{6-[2-(1-pyridin-2-ylmethyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide(1053728-82-7)

Safety Data

• Hazardous Substances Data: 1053728-82-7(Hazardous Substances Data)

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Relevant articles and documents

N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.