105394-83-0 Usage
Description
Decarboxy Ciprofloxacin is an impurity derived from the synthesis of Ciprofloxacin, a widely used fluoroquinolone antibiotic. It is an off-white solid and is considered a byproduct in the production of Ciprofloxacin.
Uses
Used in Pharmaceutical Industry:
Decarboxy Ciprofloxacin is used as a reference material for the identification and quantification of impurities in the synthesis process of Ciprofloxacin. This helps ensure the quality and purity of the final antibiotic product.
Used in Research and Development:
Decarboxy Ciprofloxacin is used as a research compound for studying the chemical properties and behavior of Ciprofloxacin impurities. This can aid in the development of improved synthesis methods and the reduction of impurities in the final product.
Used in Quality Control:
Decarboxy Ciprofloxacin is used as a reference standard in quality control testing of Ciprofloxacin products. It helps to establish the acceptable limits of impurities in the final drug, ensuring patient safety and the efficacy of the medication.
Used in Analytical Method Development:
Decarboxy Ciprofloxacin is used in the development and validation of analytical methods for the detection and quantification of impurities in Ciprofloxacin. This is crucial for maintaining the quality and consistency of the antibiotic in the pharmaceutical market.
Check Digit Verification of cas no
The CAS Registry Mumber 105394-83-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,9 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 105394-83:
(8*1)+(7*0)+(6*5)+(5*3)+(4*9)+(3*4)+(2*8)+(1*3)=120
120 % 10 = 0
So 105394-83-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H18FN3O/c17-13-9-12-14(10-15(13)19-7-4-18-5-8-19)20(11-1-2-11)6-3-16(12)21/h3,6,9-11,18H,1-2,4-5,7-8H2
105394-83-0Relevant articles and documents
Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors
Ge, Raoling,Zhao, Qian,Xie, Zhouling,Lu, Lu,Guo, Qinglong,Li, Zhiyu,Zhao, Li
, p. 465 - 474 (2016)
The design and synthesis of a new series of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives, built on the structure of 1-ethyl-3-(6-nitrobenzoxazol-2-yl)-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4(1H)-quinolone, are described. These compounds provide
Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones
Marks, Kevin R.,Malik, Muhammad,Mustaev, Arkady,Hiasa, Hiroshi,Drlica, Karl,Kerns, Robert J.
experimental part, p. 4585 - 4588 (2011/09/15)
Novel fluoroquinolone derivatives substituted with a 2-thioalkyl moiety, with and without a concomitant 3-carboxylate group, were synthesized to evaluate the effect of C-2 thioalkyl substituents on gyrase binding and inhibition. The presence of a 2-thioalkyl group universally decreased activity as compared to parent fluoroquinolones. However, with derivatives of moxifloxacin the presence of either a 2-thioalkyl group or a 3-carboxylate moiety increased activity over the 2,3-unsubstituted derivative. Energy minimization of structures provides an explanation for relative activities of fluoroquinolones having a C-2 thio moiety.
Photochemistry of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)quinoline-3- carboxylic acid (=ciprofloxacin) in aqueous solutions
Mella, Mariella,Fasani, Elisa,Albini, Angelo
, p. 2508 - 2519 (2007/10/03)
The 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)quinoline-3- carboxylic acid (=ciprofloxacin; 1) undergoes low-efficiency (φ=0.07) substitution of the 6-fluoro by an OH group on irradiation in H2O via the ππ* triplet (detected by
