105443-02-5Relevant articles and documents
B(C6F5)3-Catalyzed Tandem Friedel-Crafts and C?H/C?O Coupling Reactions of Dialkylanilines
Zhai, Gaowen,Liu, Xueting,Ma, Wentao,Wang, Guoqiang,Yang, Liu,Li, Shuhua,Wu, Youting,Hu, Xingbang
supporting information, p. 3082 - 3086 (2020/09/09)
Tandem Friedel-Crafts (FC) and C?H/C?O coupling reactions catalyzed by tris(pentafluorophenyl) borane (B(C6F5)3) were achieved without using any other additive in the absence of solvent. This process can be used for the reactions between a series of dialkylanilines and vinyl ethers with good isolated yields of bis(4-dialkylaminophenyl) compounds. Based on combined theoretical and experimental studies, the possible reaction mechanism was proposed. B(C6F5)3 can activate the C=C and C?O bond for FC and C?H/C?O coupling reactions respectively. The FC reaction is slow, which is followed by a fast C?H/C?O coupling.