10545-45-6

Basic information

• Product Name: Benzenamine, N-methyl-N-(1-methylethyl)-
• CAS NO: 10545-45-6
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Mol File: 10545-45-6.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-methyl-N-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-methyl-N-(1-methylethyl)-(10545-45-6)
• EPA Substance Registry System: Benzenamine, N-methyl-N-(1-methylethyl)-(10545-45-6)

Safety Data

• Hazardous Substances Data: 10545-45-6(Hazardous Substances Data)

Upstream product

• 380229-62-9 N-isopropyl-N-phenylglycine 
• 50-00-0 formaldehyd 
• 768-52-5 N-Isopropylaniline 
• 64-18-6 formic acid 
• 52008-97-6 N-isopropyl-N-phenylformamide 
• 100-39-0 benzyl bromide 
• 614-30-2 N-methyl-N-phenyl-benzenemethanamine 
• 75-30-9 2-iodo-propane 
• 100-61-8 N-methylaniline 
• 124-38-9 carbon dioxide 
• 62-53-3 aniline 
• 67-64-1 acetone 
• 100461-68-5 isopropylmethylphenylsulfonium perchlorate 
• 75-91-2 tert.-butylhydroperoxide 

Downstream Products

• 20914-20-9 isopropyl-phenyl-carbamonitrile 
• 61684-98-8 4-(N-isopropyl-N-methylamino)phenyl bromide 
• 35616-26-3 N-isopropyl-N,N-dimethyl-anilinium; iodide 
• 50-00-0 formaldehyd 
• 768-52-5 N-Isopropylaniline 

Relevant articles and documents

Tungstate catalysis: Pressure-switched 2- and 6-electron reductive functionalization of CO2 with amines and phenylsilane

An efficient and environmentally benign tungstate catalyst for reductive functionalization of CO2 with amines and phenylsilane was developed. By simply varying the pressure, 2-electron or 6-electron reduction of CO2 was successfully achieved with simultaneous C-N bond formation, thus leading to the formation of formamides and methylamines, respectively. That is, secondary and primary amines furnished the corresponding methylamines or dimethylamines in excellent yields under atmospheric pressure of CO2, while various formamides were formed in yields ranging from 52% to 98% when increasing the CO2 pressure to 2 MPa. 1H NMR studies and control experiments demonstrate that N-formylation proceeds through the formation of silyl formate, while N-methylation proceeds through an aminal intermediate generated by 4-electron reduction of CO2.

Dirhodium-Catalyzed Chemo-and Site-Selective C-H Amidation of N, N-Dialkylanilines

A method for dirhodium-catalyzed C(sp 3)-H amidation of N, N-dimethylanilines was developed. Chemoselective C(sp 3)-H amidation of N-methyl group proceeded exclusively in the presence of C(sp 2)-H bonds of the electron-rich aromatic ring. Site-selective C(sp 3)-H amidation proceeded exclusively at the N-methyl group of N-methyl-N-Alkylaniline derivatives with secondary, tertiary, and benzylic C(sp 3)-H bonds α to a nitrogen atom.

-

-

Reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3as a reductant

Herein, we report the first example of efficient reductive amination of ketones/aldehydes with amines using BH3N(C2H5)3 as a catalyst and a reductant under mild conditions, affording various tertiary and secondary amines in excellent yields. A mechanistic study indicates that BH3N(C2H5)3 plays a dual function role of promoting imine and iminium formation and serving as a reductant in reductive amination. This journal is

CO2-tuned highly selective reduction of formamides to the corresponding methylamines

We herein describe an efficient, CO2-tuned and highly selective C-O bond cleavage of N-methylated formanilides. With easy-to-handle and commercially available NaBH4 as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments.