1055943-40-2

Basic information

• Product Name: (E)-4-(diMethylaMino)but-2-enoyl chloride
• Synonyms: (E)-4-(diMethylaMino)but-2-enoyl chloride;4-(DIMETHYLAMINO)BUT-2-ENOYL CHLORIDE
• CAS NO: 1055943-40-2
• Molecular Formula: C₆H₁₀ClNO*ClH
• Molecular Weight: 147.6027
• EINECS: -0
• Mol File: 1055943-40-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-4-(diMethylaMino)but-2-enoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(diMethylaMino)but-2-enoyl chloride(1055943-40-2)
• EPA Substance Registry System: (E)-4-(diMethylaMino)but-2-enoyl chloride(1055943-40-2)

Safety Data

• Hazardous Substances Data: 1055943-40-2(Hazardous Substances Data)

Usage

Description

(E)-4-(Dimethylamino)but-2-enoyl chloride, with the molecular formula C8H14ClNO, is a yellowish liquid chemical compound. It features a reactive acyl chloride functional group, which is instrumental in various organic reactions such as acylation and amidation. (E)-4-(diMethylaMino)but-2-enoyl chloride is also recognized for its role as a key reagent in the synthesis of heterocyclic compounds and serves as a building block in organic chemistry research. Its versatility makes it a valuable component in the pharmaceutical and chemical industries for a wide range of applications.

Uses

Used in Pharmaceutical Industry:
(E)-4-(Dimethylamino)but-2-enoyl chloride is used as an intermediate for the synthesis of pharmaceuticals due to its reactive nature and ability to participate in organic reactions. It aids in the creation of new drug molecules and contributes to the development of novel therapeutics.
Used in Dye Industry:
In the dye industry, (E)-4-(Dimethylamino)but-2-enoyl chloride is utilized as an intermediate for synthesizing various dyes. Its chemical properties allow for the production of a range of colored compounds used in different applications, including textiles, inks, and pigments.
Used in Organic Chemistry Research:
(E)-4-(Dimethylamino)but-2-enoyl chloride is used as a building block and key reagent in organic chemistry research. It is essential for the synthesis of heterocyclic compounds, which are vital in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in Material Development:
(E)-4-(diMethylaMino)but-2-enoyl chloride is also employed in the development of new materials. Its unique properties and reactivity contribute to the creation of innovative materials with potential applications in various industries, such as electronics, aerospace, and automotive.

Upstream product

• 98548-81-3 trans-4-dimethylaminocrotonic acid hydrochloride 
• 1130155-48-4 (E)-4-(dimethylamino)-2-butenoic acid hydrochloride 
• 79-37-8 oxalyl dichloride 
• 1421354-12-2 (E)-4-dimethylamino-but-2-enoic acid tert-butyl ester 

Downstream Products

• 544417-30-3 (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide 
• 698387-09-6 neratinib 
• 850140-72-6 afatinib 
• 1363358-89-7 (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-(((spiro[3.5]octan-2-yl)methoxy)quinazolin-6-yl)-4-dimethylamino]-crotonamide 
• 1144561-12-5 (E)-N-(3-(6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-pyrimidin-4-ylamino)phenyl)-4-(dimethylamino)but-2-enamide 

Relevant articles and documents

Preparation method of neratinib

The invention relates to a preparation method of neratinib. The preparation method specifically comprises the steps: (1) in an organic solvent 1, trans-4-dimethylaminocrotonic acid hydrochloride and achloride agent react, and thus a solution containing (e)-4-(dimethylamino)but-2-enoyl chloride (hydrochloride) is obtained; (2) a solution of an organic solvent 2 containing 6-amino-4-[[3-chloro-4-[(pyridine-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinoline is added into the solution obtained in the step (1) to react, and then neratinib hydrochloride is obtained; and (3) the neratinib hydrochloride obtained in the step (2) is mixed with water and an organic solvent 3, a reaction is carried out after the pH value is regulated to be 7-10, and then the neratinib is obtained. The synthesis method has the advantages that the yield is high, the product purity is high, the production cost is low, operation is safe, easy and convenient, and large-scale industrial production is easy.

QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a quinazoline derivative, a preparation method therefor, and a pharmaceutical composition and an application thereof. The present invention provides a compound represented by general formula I, a stereoisomer thereof and a pharmaceutical acceptable salt or a solvate thereof. The quinazoline derivative of the present invention has a unique chemical structure, is characterized by irreversibly inhibiting EGFR tyrosine kinase, has high biological activity, apparently improves the inhibiting effect on the EGFR tyrosine kinase, has quite strong tumor inhibiting effect on tumor cells and a transplantation tumor pathological model of animal tumors, and has good market developing prospects.

Method for purifying neratinib

The invention relates to a method for purifying neratinib. The method provided by the invention is capable of effectively reducing the content of impurities in neratinib and preparing high-purity neratinib, and moreover is simple in operation, high in yield and very applicable to industrial production.