1055988-98-1Relevant articles and documents
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
Tremblay, Martin R.,Lescarbeau, André,Grogan, Michael J.,Tan, Eddy,Lin, Grace,Austad, Brian C.,Yu, Lin-Chen,Behnke, Mark L.,Nair, Somarajan J.,Hagel, Margit,White, Kerry,Conley, James,Manna, Joseph D.,Alvarez-Diez, Teresa M.,Hoyt, Jennifer,Woodward, Caroline N.,Sydor, Jens R.,Pink, Melissa,MacDougall, John,Campbell, Matthew J.,Cushing, Jill,Ferguson, Jeanne,Curtis, Michael S.,McGovern, Karen,Read, Margaret A.,Palombella, Vito J.,Adams, Julian,Castro, Alfredo C.
experimental part, p. 4400 - 4418 (2010/03/02)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog pathwa
