1056032-86-0

Basic information

• Product Name: C₄₈H₆₆O₈
• Synonyms: C₄₈H₆₆O₈
• CAS NO: 1056032-86-0
• Molecular Weight: 771.047
• Mol File: 1056032-86-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₈H₆₆O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₈H₆₆O₈(1056032-86-0)
• EPA Substance Registry System: C₄₈H₆₆O₈(1056032-86-0)

Safety Data

• Hazardous Substances Data: 1056032-86-0(Hazardous Substances Data)

Upstream product

• 1056032-85-9 C₅₄H₈₀O₈Si 

Downstream Products

• 1056032-77-9 C₃₄H₅₄O₈ 
• 54156-67-1 Isolasalocid A 

Relevant articles and documents

Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: Direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

Polyether metabolites are an important class of natural products. Although their biosynthesis, especially construction of polyether skeletons, attracted organic chemists for many years, no experimental data on the enzymatic polyether formation has been obtained. In this study, a putative epoxide hydrolase gene lsd19 found on the biosynthetic gene cluster of an ionophore polyether lasalocid was cloned and successfully overexpressed in Escherichia coli. Using the purified Lsd19, a proposed substrate, bisepoxyprelasalocid, and its synthesized analogue were successfully converted into lasalocid A and its derivative via a 6-endo-tet cyclization mode. On the other hand, treatment of the bisepoxide with trichloroacetic acid gave isolasalocid A via a 5-exo-tet cyclization mode. Therefore, the enzymatic conversion observed in this study unambiguously showed that the bisepoxyprelasalocid is an intermediate of the lasalocid biosynthesis and that Lsd19 catalyzes the sequential cyclic ether formations involving an energetically disfavored 6-endo-tet cyclization. This is the first example of the enzymatic epoxide-opening reactions leading to a polyether natural product. Copyright