105623-17-4

Basic information

• Product Name: N-(2-methylpropylidene)benzylamine-N-oxide
• CAS NO: 105623-17-4
• Molecular Weight: 177.246
• Mol File: 105623-17-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N-(2-methylpropylidene)benzylamine-N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methylpropylidene)benzylamine-N-oxide(105623-17-4)
• EPA Substance Registry System: N-(2-methylpropylidene)benzylamine-N-oxide(105623-17-4)

Safety Data

• Hazardous Substances Data: 105623-17-4(Hazardous Substances Data)

Upstream product

• 625-74-1 1-nitroisobutane 
• 1589-82-8 phenylmagnesium bromide 
• 622-32-2 (Z)-benzaldehyde oxime 
• 823817-60-3 C₁₁H₁₆N₂O₃ 
• 622-30-0 N-benzyl hydroxylalmine 
• 227804-37-7 C₁₂H₁₇NO₂ 
• 78-84-2 isobutyraldehyde 
• 932-90-1 Benzaldoxime 
• 100-52-7 benzaldehyde 
• 932-90-1 syn-benzaldehyde oxime 
• 100-46-9 benzylamine 
• 16975-39-6 2-(benzylamino)-3-methylbutanoic acid 
• 15363-84-5 (S)-2-(benzylamino)-3-methylbutanoic acid 

Downstream Products

• 198694-24-5 N-Benzyl-N-(1-isopropyl-but-3-enyl)-hydroxylamine 
• 254762-82-8 N-benzyl-N-(1-isopropyl-5-phenyl-pent-2-ynyl)-hydroxylamine 
• 439129-40-5 2-benzyl-3-isopropyl-4,5-bis(trimethylsilyl)-4-isoxazoline 
• 1373129-27-1 benzyl 4-[benzyl(hydroxy)amino]-5-methyl-3-(propan-2-ylidene)hexanoate 
• 1373129-21-5 ethyl 4-[benzyl(hydroxy)amino]-5-methyl-3-methylenehexanoate 
• 1147131-05-2 1-benzyl-5-isopropylpyrrolidine-2,4-dione 
• 1373129-28-2 1-benzyl-5-isopropyl-4-methylenepyrrolidin-2-one 
• 86170-45-8 benzyl 3-butenoate 
• 1373129-13-5 benzyl 4-[benzyl(hydroxy)amino]-5-methyl-3-methylenehexanoate 
• 1373129-22-6 tert-butyl 4-[benzyl(hydroxy)amino]-5-methyl-3-methylenehexanoate 
• 1434058-69-1 C₂₃H₃₄N₂OS 

Relevant articles and documents

Synthesis of 4-Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic N-Hydroxylamines

New catalytic methods for the synthesis of 4-isoxazolines have been developed via catalytic intramolecular cyclizations of propargylic N-hydroxylamines. The reactions proceed rapidly in less than 1 h at room temperature in the presence of 5 mol % (PPh3)AuCl/5 mol % AgOTf or 5 mol % (PPh3)AuNTf2. This process features an efficient route to 4-isoxazolines with high yields, short reaction times, and mild reaction conditions.

Reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols

(Chemical Equation Presented) We report the reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols. The latter are obtained in high diastereoselectivity with preference for the syn isomer.

Solid-phase synthesis of hydroxypiperazine derivatives using phenethylamine linker by oxidation-Cope elimination

A general method is reported for the parallel solid-phase synthesis of hydroxypiperazine derivatives based on the oxidation-Cope elimination of polymer-bound phenethylamine linker with m-CPBA. The key intermediate of phenethylamine N-oxide resins was separable on solid-phase for subsequent β-elimination, from which the desired hydroxypiperazine products could be obtained in high purities and yields without any significant contamination at 90°C for 2 h. The utility of the methodology for solid-phase synthesis of general hydroxylamines was also investigated using the same linker. The progress of reactions could be monitored on polymer bound intermediates by ATR-FTIR spectroscopy on single bead. The desired products were obtained in good six-step overall yields upon cleavage from the resins and were characterized by LC/MS, 1H NMR, and 13C NMR spectroscopy.