105637-50-1 Usage
Description
ML-9 HYDROCHLORIDE is a crystalline solid that inhibits the catalytic activities of several protein kinases competitively with respect to ATP, exhibiting different Ki values toward each protein kinase. It has also been identified as a new type of vascular relaxant.
Uses
Used in Pharmaceutical Industry:
ML-9 HYDROCHLORIDE is used as a pharmaceutical compound for its ability to inhibit the catalytic activities of various protein kinases. This makes it a potential candidate for the development of treatments targeting conditions related to protein kinase dysregulation.
Used in Cardiovascular Applications:
ML-9 HYDROCHLORIDE is used as a vascular relaxant, which can help in the treatment and management of cardiovascular diseases by promoting blood vessel relaxation and improving blood flow.
Used in Research and Development:
ML-9 HYDROCHLORIDE is used as a research tool in the study of protein kinases and their roles in various biological processes. Its ability to inhibit these enzymes competitively with respect to ATP makes it a valuable compound for understanding the mechanisms of protein kinase regulation and their potential as therapeutic targets.
Biological Activity
Selective inhibitor of myosin light chain kinase (MLCK). K i values are 32, 4, and 54 μ M for PKA, MLCK, and PKC respectively. Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca 2+ entry (SOCE).
Check Digit Verification of cas no
The CAS Registry Mumber 105637-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,6,3 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 105637-50:
(8*1)+(7*0)+(6*5)+(5*6)+(4*3)+(3*7)+(2*5)+(1*0)=111
111 % 10 = 1
So 105637-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
