105661-40-3 Usage
Description
3-AZIDO-L-ALANINE, also known as Nβ-Azido-L-2,3-Diaminopropionic Acid, is a white crystalline powder with unique chemical properties. It is a compound that has found applications in various fields due to its reactivity and structural characteristics.
Uses
Used in Pharmaceutical Industry:
3-AZIDO-L-ALANINE is used as a reagent for the development of osteoprotegerin-like glycopeptides. It plays a crucial role in the synthesis process, contributing to the creation of these bioactive molecules that have potential applications in bone metabolism and related therapeutic areas.
Used in Chemical Synthesis:
3-AZIDO-L-ALANINE is also used in the synthesis of macrocyclic peptides. Its unique structure allows for the formation of cyclic peptide structures, which are important in various biological and pharmaceutical applications, including drug development and the study of protein-protein interactions.
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 105661-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,6,6 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 105661-40:
(8*1)+(7*0)+(6*5)+(5*6)+(4*6)+(3*1)+(2*4)+(1*0)=103
103 % 10 = 3
So 105661-40-3 is a valid CAS Registry Number.
InChI:InChI=1/C3H6N4O2/c1-2(3(8)9)5-7-6-4/h2,5H,1H3,(H,8,9)/t2-/m0/s1
105661-40-3Relevant articles and documents
Presentation and detection of azide functionality in bacterial cell surface proteins
Link, A. James,Vink, Mandy K. S.,Tirrell, David A.
, p. 10598 - 10602 (2004)
An improved protocol for copper-catalyzed triazole formation on the bacterial cell surface is described. Addition of highly pure CuBr to cells treated with azidohomoalanine (2) leads to ca. 10-fold more extensive cell surface labeling than previously observed. This highly active catalyst allows detection of the methionine analogues azidoalanine (1), azidonorvaline (3), and azidonorleucine (4) in cell surface proteins. Azidoalanine was previously believed to be silent with regard to the cellular protein synthesis machinery.
A concise route to L-azidoamino acids: L-azidoalanine, L-azidohomo-alanine and L-azidonorvaline
Roth, Stefanie,Thomas, Neil R.
scheme or table, p. 607 - 609 (2010/09/18)
A simple and highly efficient synthetic route to three homologous azidoamino acids, starting from inexpensive, commercially available, protected natural amino acids is reported. The products can be used to introduce bioorthogonal handles into proteins. Ge