105678-40-8

Basic information

• Product Name: (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide
• Synonyms: (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide
• CAS NO: 105678-40-8
• Molecular Weight: 233.19
• Mol File: 105678-40-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide(105678-40-8)
• EPA Substance Registry System: (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide(105678-40-8)

Safety Data

• Hazardous Substances Data: 105678-40-8(Hazardous Substances Data)

Upstream product

• 80866-87-1 α-methoxy-α-trifluoromethyl-phenyl-acetonitrile 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 93923-55-8 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 

Downstream Products

• 20445-31-2 MTPA 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 17257-71-5 (S)-Mosher acid 

Relevant articles and documents

A MODIFIED SYNTHESIS OF MOSHER'S ACID AND ITS USE IN A SENSITIVE STEREOISOMER ANALYSIS OF AMINO ACID DERIVATIVES

A convenient and sensitive method for stereoisomer analysis of amino acid derivatives is described.It is based on the (19)F NMR-analysis of mixtures containing epimers of N-.-methoxy-.-trifluoromethyl-phenylacetyl alanine (MTPA).An improved procedure for the synthesis of MTPA is given.

PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND USES THEREOF

The invention relates to compounds of formula (I) that are inhibitors of hypoxanthine and/or guanine purine phosphoribosyltransferases and to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in which it is desirable to inhibit hypoxanthine and/or guanine purine phosphoribosyltransferases. Such diseases include malaria.

Biosynthesis of porphyrins and related macrocycles. Part 52.1'2 Synthesis of 1-SH11-4Hjporphobilinogen and the (11R)enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

A synthetic route is devised for the synthesis of (115)-[11-2H,]porphobilinogen la and of the (1 lβ)-enantiomer Ib. Their absolute configurations and enantiomeric purity are established by degradation to a derivative of [2-2H,]glycine of known stereochemistry. Methods are then developed, based on the synthesis of chiral imidate esters, for determination of the configuration of [2H1]-labelled aminomethylpyrroles by converting them into [2H,]-labelled amidines followed by analysis using 'H-NMR. The labelled samples of PEG la and Ib serve as substrates for hydroxymethylbilane synthase and the products are trapped as [2H1]-labelIed aminomethylbilanes 7c and 7d. Their configurations are determined by the NMR assay to demonstrate that as PBG 1 is enzymically converted into the aminomethylbilane 7, there is overall retention of configuration at the aminomethyl carbon. The Royal Society of Chemistry 1999.