10569-12-7

Basic information

• Product Name: Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran
• Synonyms: (-)-Galbelgin;(2S)-2α,5β-Bis(3,4-dimethoxyphenyl)tetrahydro-3β,4α-dimethylfuran;Galbelgin
• CAS NO: 10569-12-7
• Molecular Formula: C₂₂H₂₈O₅
• Molecular Weight: 372.45472
• Mol File: 10569-12-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran(10569-12-7)
• EPA Substance Registry System: Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran(10569-12-7)

Safety Data

• Hazardous Substances Data: 10569-12-7(Hazardous Substances Data)

Usage

Description

Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran is a synthetic chemical compound that belongs to the class of furan derivatives. It features a heterocyclic ring structure composed of four carbon atoms and one oxygen atom, with multiple substituent groups such as dimethoxyphenyl and dimethyl groups attached to specific carbon atoms. This complex structure suggests that the compound may possess unique properties and potential applications, particularly in the fields of medicine and research. However, further investigation and testing are required to fully understand its capabilities and effects.

Uses

Used in Pharmaceutical Industry:
Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran is used as a potential pharmaceutical candidate due to its unique chemical structure and properties. Its heterocyclic nature and substituent groups may contribute to its interaction with biological targets, making it a promising compound for the development of new drugs and therapies.
Used in Chemical Research:
In the field of chemical research, Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran serves as a valuable compound for studying the properties and behavior of furan derivatives. Its complex structure allows researchers to explore various aspects of chemistry, such as synthesis, reactivity, and potential applications in different chemical processes.
Used in Material Science:
Tetrahydro-2α,5β-bis(3,4-dimethoxyphenyl)-3β,4α-dimethylfuran may also find applications in material science, where its unique structure and properties can be utilized to develop new materials with specific characteristics. These materials could have potential uses in various industries, such as electronics, coatings, or advanced materials for specific applications.

Upstream product

• 50393-85-6 nectandrin-B 
• 77-78-1 dimethyl sulfate 
• 1262323-70-5 C₂₁H₂₆O₅ 
• 74-88-4 methyl iodide 
• 1262222-71-8 C₂₄H₂₈O₆ 
• 1262222-72-9 C₃₀H₃₈O₇ 
• 1262222-73-0 C₂₃H₂₆O₇ 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 727428-95-7 (3R,2'S)-(1',4'-dioxa-spiro[4.5]dec-2'-yl)-pent-4-enoic acid ethyl ester 
• 4440-92-0 (2S*,3S*)-1,4-bis(3,4-dimethoxyphenyl)-2,3-dimethylbutane-1,4-dione 
• 50393-85-6 C₂₀H₂₄O₅ 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 37629-53-1 (E)-1,2-dimethoxy-4-(2-nitroprop-1-enyl)benzene 
• 31706-95-3 1'-Hydroxymethyleugenol 

Downstream Products

• 19950-58-4 2r,5c-Bis-(4,5-dimethoxy-2-nitro-phenyl)-3c,4c-dimethyl-tetrahydro-furan 
• 3569-00-4 (+/-)-trans-4-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-2,3-dimethylnaphthalene 
• 528-63-2 galgravin 
• 521-54-0 (7S,8S,8'R)-3,4,3',4'-tetramethoxy-7,6',8,8'-neolignan (-)-galbulin 
• 5811-91-6 1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-2,3-dimethyl-naphthalene 
• 73366-01-5 (7'S,8'R)-3',4',4,5-tetramethoxy-2,7'-cyclolignan-7-ene 
• 521-54-0 (±)-galbulin 
• 50393-85-6 (+)-fragransin A₂ 
• 83198-63-4 (+)-verrucosin 

Relevant articles and documents

Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies

The development and characterization of enantioselective catalytic kinetic resolution of allylic alcohols through asymmetric isomerization with chiral BINOL derivatives-based alkoxides as bifunctional Br?nsted base catalysts were described in the study. A number of chiral BINOL derivatives-based alkoxides were synthesized, and their structure-enantioselectivity correlation study in asymmetric isomerization identified a promising chiral Br?nsted base catalyst, which afforded various chiral secondary allylic alcohols (ee up to 99%, S factor up to >200). In the mechanistic study, alkoxide species were identified as active species and the phenol group of BINOL largely affected the high reactivity and enantioselectivity via hydrogen bonding between the chiral Br?nsted base catalyst and substrates. The strategy is the first successful synthesis strategy of various chiral secondary allylic alcohols through enantioselective transition-metal-free base-catalyzed isomerization. The applicability of the strategy had been demonstrated by the synthesis of the bioactive natural product (+)-veraguensin.

Synthesis of nordihydroguaiaretic acid derivatives and their bioactivities on S. pombe and K562 cell lines

Nordihydroguaiaretic acid (NDGA) and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral and bacterial infections, and inflammation. In this paper, we report the optimal synthetic methods and the bioactivity study of terameprocol 2, NDGA derivative 3, and its cyclized analogue 4. The IC50 of these three compounds 2, 3 and 4 on the growth metabolism of Schizosacchromyces pombe and K562 cell lines were determined by microcalorimetry. The preliminary results showed that the compounds 2, 3 and 4 possessed good inhibition activities on S. pombe and K562 cell lines, and exhibited bidirectional biological effect and Hormesis effect. In particular, terameprocol 2 was found to possess the most potent inhibitory effect on K562 cell lines.

Tetrahydrofuran lignans via tandem oxidative anionic-radical processes or reductive radical cyclizations

Several tetrahydrofuran lignans have become important due to their diverse biological activities. We present initial studies on short syntheses of some of the simplest members of this natural product class. Galgravin and Veraguensin are obtained in only t