1056991-19-5

Basic information

• Product Name: 2-azido-N-cyclohexyl-N-phenylacetamide
• Synonyms: 2-azido-N-cyclohexyl-N-phenylacetamide
• CAS NO: 1056991-19-5
• Molecular Weight: 258.323
• Mol File: 1056991-19-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-azido-N-cyclohexyl-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-azido-N-cyclohexyl-N-phenylacetamide(1056991-19-5)
• EPA Substance Registry System: 2-azido-N-cyclohexyl-N-phenylacetamide(1056991-19-5)

Safety Data

• Hazardous Substances Data: 1056991-19-5(Hazardous Substances Data)

Upstream product

• 100721-33-3 2-chloro-N-cyclohexyl-N-phenylacetamide 
• 1821-36-9 N-phenyl-2-cyclohexylamine 
• 100722-07-4 iodo-acetic acid-(N-cyclohexyl-anilide) 
• 870070-76-1 2-amino-N-cyclohexyl-N-phenylacetamide 

Downstream Products

• 870070-76-1 2-amino-N-cyclohexyl-N-phenylacetamide 
• 1093975-41-7 N-cyclohexyl-2-{4-[3-methoxy-4-(4-methylimidazol-1-yl)-phenyl]-1,2,3-triazol-1-yl}-N-phenylacetamide 

Relevant articles and documents

Triazoloamides as potent γ-secretase modulators with reduced hERG liability

Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from our aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole 57 was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC 50 in cell-based assays and reduced affinity for the hERG channel.

COMPOUNDS OF THE FORMU;A R1-X-Y-Z-NR2R3 AS ABCA-1 ELEVATING AGENTS AGAINST CAD OR ATHEROSCLEROSIS

The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary