105706-76-1 Usage
Description
1-CBZ-PIPERIDINE-2-ALDEHYDE, also known as N-Carbobenzyloxy-Piperidine-2-aldehyde, is an organic compound that belongs to the class of aldehydes. It is characterized by the presence of a carbobenzyloxy (Cbz) group attached to a piperidine ring, with an aldehyde functional group at the 2-position. 1-CBZ-PIPERIDINE-2-ALDEHYDE is known for its reactivity and is commonly utilized in various chemical and pharmaceutical applications due to its unique structural features.
Uses
Used in Chemical Synthesis:
1-CBZ-PIPERIDINE-2-ALDEHYDE is used as a reactant in the kinetic resolution of racemic amino aldehydes. This process involves the selective oxidation of one enantiomer over the other, leading to the formation of chiral products with high enantiomeric purity. The use of copper(II)/(R,R)-Ph-BOX complex as a catalyst and N-iodosuccinimide as an oxidizing agent ensures a highly selective and efficient reaction.
Used in Pharmaceutical Industry:
1-CBZ-PIPERIDINE-2-ALDEHYDE serves as an important intermediate in the synthesis of various pharmaceutical compounds, particularly those with piperidine-based structures. Its unique reactivity and functional groups make it a valuable building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Research and Development:
In the field of research and development, 1-CBZ-PIPERIDINE-2-ALDEHYDE is employed as a key compound for exploring new reaction pathways and understanding the reactivity of aldehydes with different catalysts and reagents. This knowledge can be applied to the design and synthesis of novel molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 105706-76-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,0 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 105706-76:
(8*1)+(7*0)+(6*5)+(5*7)+(4*0)+(3*6)+(2*7)+(1*6)=111
111 % 10 = 1
So 105706-76-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H17NO3/c16-10-13-8-4-5-9-15(13)14(17)18-11-12-6-2-1-3-7-12/h1-3,6-7,10,13H,4-5,8-9,11H2
105706-76-1Relevant articles and documents
Effecient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide
Minato, Daishirou,Nagasue, Yoko,Demizu, Yosuke,Onomura, Osamu
supporting information; experimental part, p. 9458 - 9461 (2009/05/06)
(Chemical Equation Presented) Selective recognition: The first efficient method for the kinetic resolution of racemic amino aldehydes (see scheme, PG=protecting group) is based on a copper(II)/(R,R)-Ph-BOX complex. The coordinated amino aldehydes were tra
Src kinase inhibitor compounds
-
, (2008/06/13)
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
The Synthesis of 1-Methyl-6,7,8,8a-tetrahydro-5H-indolizin-3-one by the Palladium-Catalyzed Cyclization of N-Bromoacetyl-2-vinylpiperidine
Yang, Shyh-Chyun,Shea, Fang-Rong,Chung, Wen-Hung
, p. 293 - 296 (2007/10/03)
N-Bromoacetyl-2-vinylpiperidine underwent cyclizalion to give indolizidine derivative in the presence of a base and a catalytic amount of palladium trifluoroacetate.