1057279-54-5

Basic information

• Product Name: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1057279-54-5
• Molecular Weight: 265.398
• Mol File: 1057279-54-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(1057279-54-5)
• EPA Substance Registry System: 2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline(1057279-54-5)

Safety Data

• Hazardous Substances Data: 1057279-54-5(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 35779-04-5 1-tert-butyl-4-iodobenzene 

Downstream Products

• 1308790-35-3 2-(4-(tert-butyl)phenyl)-1-(2-methylallyl)-1,2,3,4-tetrahydroisoquinoline 
• 1402732-48-2 1-(2-(4-(tert-butyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-propan-2-one 
• 1402732-40-4 1-(nitromethyl)-2-(4′-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1391634-87-9 (S)-2-(2-(4-tert-butylphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde 

Relevant articles and documents

Electrocatalytic C(sp3)-H/C(sp)-H cross-coupling in continuous flow through TEMPO/copper relay catalysis

Electrocatalytic dehydrogenative C(sp3)-H/C(sp)-H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

Radical alkylation of C(sp3)-H bonds with diacyl peroxides under catalyst-free conditions

Herein, we describe a protocol for alkylation reactions of C(sp3)-H bonds with diacyl peroxides by means of a process involving cross-coupling between an alkyl radical and an α-Aminoalkyl radical. The mild, catalyst-And additive-free conditions make this protocol superior to previously reported C(sp3)-H alkylation strategies. The protocol was applied to 1,2,3,4-Tetrahydroisoquinolines and a tetrahydro-β-carboline derivative and could be carried out on a gram scale, indicating its utility for the alkylation of late-stage synthetic intermediates.