1057284-07-7

Basic information

• Product Name: 4-(methoxycarbonyl)phenylethynylcyclopropane
• Synonyms: 4-(methoxycarbonyl)phenylethynylcyclopropane
• CAS NO: 1057284-07-7
• Molecular Weight: 200.237
• Mol File: 1057284-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(methoxycarbonyl)phenylethynylcyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methoxycarbonyl)phenylethynylcyclopropane(1057284-07-7)
• EPA Substance Registry System: 4-(methoxycarbonyl)phenylethynylcyclopropane(1057284-07-7)

Safety Data

• Hazardous Substances Data: 1057284-07-7(Hazardous Substances Data)

Upstream product

• 6746-94-7 Cyclopropylacetylene 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 1208119-78-1 (E)-N-(2-(4-methoxycarbonylbenzylidene)cyclobutyl)-4-methylbenzenesulfonamide 
• 1263053-79-7 methyl 4-(cyclobut-1-enecarbonyl)benzoate 
• 908247-29-0 4-(2-cyclopropylethynyl)benzoic acid 
• 1416562-12-3 methyl 4-(4-cyclopropyl-2-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl)benzoate 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Gold(l)-catalyzed ring expansions of unactivated alkynylcyclopropanes to (E)-2-alkylidenecyclobutanamines in the presence of sulfonamides

(Chemical Equation Presented) The ring expansion of cyclopropane derivatives provides a powerful method to construct synthetically useful four-membered carbocycles. Herein, a new type of gold(l)-catalyzed ring expansion of an unactivated alkynylcyclopropane/sulfonamide trapping strategy to (E)-2-alkylidenecyclobutanamines was described. The reaction tolerates a range of aryl and alkyl substituents with moderate to good yields.