10575-25-4

Basic information

• Product Name: 4-DIETHYLAMINO-2-BUTYN-1-OL
• Synonyms: 4-(N,N-Diethylamino)butyn-1-ol;(CH3CH2)2NCH2C≡CCH2OH;Einecs 234-163-6;4,4-DiethylaMino-2-butyn-1-ol, 98%;1-(DiethylaMino)-2-butyn-4-ol;1-(N,N-Diethylamino)-4-hydroxy-2-butyne;4-DIETHYLAMINO-2-BUTYN-1-OL;TIMTEC-BB SBB008755
• CAS NO: 10575-25-4
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• EINECS: 234-163-6
• Product Categories: Chemical Amines;Acetylenes;Acetylenic Alcohols & Their Derivatives;Amines;Amino Alcohols;Organic Building Blocks;Oxygen Compounds;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 10575-25-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 231-232 °C(lit.)
• Flash Point: 220 °F
• Appearance: white solid
• Density: 0.952 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0209mmHg at 25°C
• Refractive Index: n20/D 1.479(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 13.01±0.10(Predicted)
• Water Solubility: Soluble in chloroform and ethyl acetate. Soluble in water 11 g/L @25°C.
• CAS DataBase Reference: 4-DIETHYLAMINO-2-BUTYN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIETHYLAMINO-2-BUTYN-1-OL(10575-25-4)
• EPA Substance Registry System: 4-DIETHYLAMINO-2-BUTYN-1-OL(10575-25-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 10575-25-4(Hazardous Substances Data)

Usage

Description

4-DIETHYLAMINO-2-BUTYN-1-OL, also known as 4,4-Diethylamino-2-butyn-1-ol, is an organic compound characterized by its white solid appearance. It is a derivative of butynol with a diethylamino group attached at the 4th position, which contributes to its unique chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
4-DIETHYLAMINO-2-BUTYN-1-OL is used as a pharmaceutical intermediate for the synthesis of various medications. Its unique chemical structure allows it to serve as a building block in the development of new drugs, particularly in the field of medicinal chemistry.
Used as an Impurity in Oxybutynin:
In the pharmaceutical context, 4-DIETHYLAMINO-2-BUTYN-1-OL is also recognized as an impurity in the synthesis of Oxybutynin, a medication used to treat overactive bladder and other urinary conditions. The presence of this impurity is carefully monitored and controlled to ensure the safety and efficacy of the final drug product.

InChI:InChI=1/C8H15NO/c1-3-9(4-2)7-5-6-8-10/h10H,3-4,7-8H2,1-2H3

Upstream product

• 35331-62-5 {4-[1-(4-Diethylamino-but-2-ynyloxy)-ethoxy]-but-2-ynyl}-diethyl-amine 
• 50-00-0 formaldehyd 
• 107-19-7 propargyl alcohol 
• 109-89-7 diethylamine 
• 13125-60-5 butoxymethyldiethylamine 
• 5633-20-5 oxybutynin 
• 1508-65-2 Oxybutynin chloride 
• 660-68-4 diethyl amine hydrochloride 
• 10575-22-1 1-Butyloxy-1-<4-diethylamino-butin-(2)-yloxy>-ethan 
• 13280-07-4 4-chlorobut-2-yn-1-ol 

Downstream Products

• 2683-56-9 4-(N,N-diethylamino)-1-butanol 
• 6749-55-9 4-(diethylamino)but-2-yn-1-yl benzoate 
• 22396-77-6 acetic acid-(4-diethylamino-but-2-ynyl ester) 
• 24642-32-8 4-diethylamino-2-butynyl 1-phenylcyclopentanecarboxylate 
• 100958-41-6 p-Nitro-benzoesaeure-<4-diaethylamino-butin-(2)-ylester> 
• 109866-21-9 o-Toluylsaeure-(4-diethylamino-but-2-inylester) 
• 109866-91-3 m-Toluylsaeure-(4-diethylamino-but-2-inylester) 
• 65597-94-6 (E)-2-Phenyl-4-diethylamino-2-buten-1-ol 
• 4079-68-9 N,N-diethyl-2-propynylamine 
• 144313-99-5 1-cyclohexyl-2-(4-diethylamino-2-butynyloxy)-1-phenylethanol 
• 18913-31-0 2,3-butadien-1-ol 
• 78489-25-5 4-diethylamino-2-butynyl N-phenylcarbamate 
• 1315323-57-9 C₂₃H₃₄N₂OSi 
• 1207344-05-5 (+)-Oxybutynin hydrochloride 

Relevant articles and documents

High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products

Two high performance liquid chromatographic (HPLC) methods are presented for the determination of oxeladin citrate (OL) and oxybutynin hydrochloride (OB) and their degradation products. The first method was based on HPLC separation of OL from its degradation product using a Nucleosil C18 column with a mobile phase consisting of acetonitrile -0.1% phosphoric acid (60:40 v/v). The second method was based on HPLC separation of OB from its degradation product using a VP-ODS C18 column with a mobile phase consisting of acetonitrile/0.01:M potassium dihydrogen phosphate/diethylamine (60:40:0.2). Quantitation was achieved with UV detection at 220:nm based on peak area. The two HPLC methods were applied for the determination of OL or OB, their degradation products, methylparaben and propylparaben in pharmaceutical preparations. The proposed methods were used to investigate the kinetics of acidic and alkaline degradation processes of OL and OB at different temperatures and the apparent pseudofirst-order rate constant, half-life and activation energy were calculated. The pH-rate profiles of degradation of OL and OB in Britton-Robinson buffer solutions within the pH range 2-12 were studied.

CRYSTALLINE OXYBUTYNIN AND PROCESS FOR PREPARING THE SAME

The present invention relates to a crystalline oxybutynin base and process for preparing the same. Further, this invention discloses a process for preparing an acid addition salt of oxybutynin employing the crystalline oxybutynin base.

Synthesis and biological evaluation of 12 allenic aromatic ethers

Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.