105751-13-1 Usage
Description
FMOC-SER(TBU)-OPFP, also known as N-(9-fluorenylmethoxycarbonyl)-L-serine tert-butyl ester with a pentafluorophenyl ester, is a protected amino acid derivative commonly utilized in the field of organic chemistry and peptide synthesis. It features a fluorenylmethoxycarbonyl (Fmoc) group for protection of the amino group, a tert-butyl (tBu) group for protection of the carboxylic acid group, and a pentafluorophenyl (OPfp) group for protection of the side-chain hydroxyl group. These protecting groups ensure the selective deprotection and coupling of the amino acid during peptide synthesis.
Uses
Used in Pharmaceutical Industry:
FMOC-SER(TBU)-OPFP is used as a building block for the synthesis of peptides and peptide derivatives, which are essential components in the development of various pharmaceutical drugs. The protected amino acid allows for the controlled assembly of peptide sequences through stepwise addition, enabling the creation of complex and biologically active molecules.
Used in Research and Development:
In the field of research and development, FMOC-SER(TBU)-OPFP serves as a valuable tool for the synthesis of novel peptide-based compounds with potential applications in various therapeutic areas. The compound can be used to explore new drug candidates, study protein-protein interactions, and develop targeted drug delivery systems.
Used in Chemical Synthesis:
FMOC-SER(TBU)-OPFP is also used as a reactant in the synthesis of various chemical compounds, including those with potential applications in materials science, agrochemicals, and other industries. The compound's unique structure and protecting groups make it a versatile building block for the development of new molecules with specific properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 105751-13-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,5 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 105751-13:
(8*1)+(7*0)+(6*5)+(5*7)+(4*5)+(3*1)+(2*1)+(1*3)=101
101 % 10 = 1
So 105751-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C28H24F5NO5/c1-28(2,3)38-13-19(26(35)39-25-23(32)21(30)20(29)22(31)24(25)33)34-27(36)37-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,34,36)/t19-/m0/s1
105751-13-1Relevant articles and documents
New solid support for the synthesis of 3′-oligonucleotide conjugates through glyoxylic oxime bond formation
Spinelli, Nicolas,Edupuganti, Om Prakash,Defrancq, Eric,Dumy, Pascal
, p. 219 - 222 (2007)
(Chemical Equation Presented) A novel solid support 1 was synthesized to incorporate glyoxylic aldehyde functionality at the oligonucleotide 3′-terminus. 6-mer and 11-mer oligonucleotide sequences containing 3′-glyoxylic aldehyde functionality were prepar
9-Fluorenylmethyl Pentafluorophenyl Carbonate as a Useful Reagent for the Preparation of N-9-Fluorenylmethyloxycarbonylamino Acids and their Pentafluorophenyl Esters
Schoen, Istvan,Kisfaludy, Lajos
, p. 303 - 305 (2007/10/02)
9-Fluorenylmethyl pentafluorophenyl carbonate is a useful reagent for the efficient, side reaction-free introduction of N-9-fluorenylmethyloxycarbonyl protecting group into amino acids and for the subsequent preparation of their pentafluorophenyl esters.Some new compounds of both types are described.
