105764-39-4 Usage
Description
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE, also known as (-)-1-(9-Fluorenyl)ethyl Chloroformate, is a chemical compound that serves as an analytical reagent. It is characterized by its ability to facilitate the chiral separation of amino acids through capillary electrophoresis, a technique widely used in the field of biochemistry and pharmaceutical analysis.
Uses
Used in Analytical Chemistry:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as an analytical reagent for the chiral separation of amino acids. This application is particularly important in the field of biochemistry and pharmaceutical analysis, where the ability to distinguish between different enantiomers of a compound is crucial for understanding the structure and function of biomolecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is used as a chiral derivatizing agent for the analysis of enantiomers. The accurate determination of enantiomers is essential for drug development, as the different forms of a molecule can have distinct biological activities and pharmacological effects. This reagent aids in the identification and quantification of these enantiomers, ensuring the safety and efficacy of pharmaceutical products.
Used in Research and Development:
(+)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE is also utilized in research and development for the study of chiral compounds and their interactions with biological systems. This reagent can be employed in various experimental setups to investigate the role of chirality in biological processes and to develop new methods for the separation and analysis of enantiomers.
Check Digit Verification of cas no
The CAS Registry Mumber 105764-39-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,7,6 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 105764-39:
(8*1)+(7*0)+(6*5)+(5*7)+(4*6)+(3*4)+(2*3)+(1*9)=124
124 % 10 = 4
So 105764-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3/t10-/m1/s1
105764-39-4Relevant articles and documents
(S)-(?)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines
Amin, Mohammad A.,Camerino, Michelle A.,Mountford, Simon J.,Ma, Xiao,Manallack, David T.,Chalmers, David K.,Wills, Martin,Thompson, Philip E.
, (2019)
Fluorenylethylchoroformate (FLEC) is a valuable chiral derivatisation reagent that is used for the resolution of a wide variety of chiral amines. Herein, we describe an improved preparation of (S)-(?)-FLEC using an efficient asymmetric catalytic transfer hydrogenation as the key step. We also demonstrate the application of FLEC as a chiral Fmoc equivalent for chiral resolution, with facile deprotection, of tetrahydroquinaldines, and its capacity for inducing regioselective outcomes in nitration reactions.
(+)-Fluorenylethylchloroformate (FLEC)-improved synthesis for application in chiral analysis and peptidomimetic synthesis
Camerino, Michelle A.,Chalmers, David K.,Thompson, Philip E.
, p. 2571 - 2573 (2013/06/05)
An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown.
