1057678-65-5 Usage
Description
1-(3-bromopropyl)-3-trifluoromethoxybenzene, also known as bromopropyl trifluoromethoxybenzene, is an organic compound characterized by its molecular formula C10H10BrF3O. It exists as a colorless liquid at room temperature and is recognized for its strong reactivity, making it a versatile intermediate in the synthesis of various compounds, including pharmaceuticals and agrochemicals. Due to its reactivity, it is frequently utilized in organic synthesis reactions such as nucleophilic substitution and Grignard reactions. However, it is essential to exercise caution when handling this compound, as it can cause skin and eye irritation and should be used in a well-ventilated area.
Uses
Used in Pharmaceutical Synthesis:
1-(3-bromopropyl)-3-trifluoromethoxybenzene is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its strong reactivity allows for the creation of a wide range of pharmaceutical compounds with different therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 1-(3-bromopropyl)-3-trifluoromethoxybenzene is employed as an intermediate in the production of various agrochemicals. Its versatility in organic synthesis reactions enables the development of compounds with specific applications in agriculture, such as pesticides and herbicides.
Used in Organic Synthesis:
1-(3-bromopropyl)-3-trifluoromethoxybenzene is used as a reactive intermediate in organic synthesis for the creation of a diverse array of organic compounds. Its participation in nucleophilic substitution and Grignard reactions contributes to the synthesis of complex organic molecules with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1057678-65-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,7,6,7 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1057678-65:
(9*1)+(8*0)+(7*5)+(6*7)+(5*6)+(4*7)+(3*8)+(2*6)+(1*5)=185
185 % 10 = 5
So 1057678-65-5 is a valid CAS Registry Number.
1057678-65-5Relevant articles and documents
Boron tribromide as a reagent for anti-Markovnikov addition of HBr to cyclopropanes
Chen, Shuming,Gieuw, Matthew H.,Houk, K. N.,Ke, Zhihai,Yeung, Ying-Yeung
, p. 9426 - 9433 (2020)
Although radical formation from a trialkylborane is well documented, the analogous reaction mode is unknown for trihaloboranes. We have discovered the generation of bromine radicals from boron tribromide and simple proton sources, such as water ortert-butanol, under open-flask conditions. Cyclopropanes bearing a variety of substituents were hydro- and deuterio-brominated to furnish anti-Markovnikov products in a highly regioselective fashion. NMR mechanistic studies and DFT calculations point to a radical pathway instead of the conventional ionic mechanism expected for BBr3
