1058062-64-8

Basic information

• Product Name: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine
• Synonyms: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine;2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoroMethyl)aniline;2-Amino-5-(trifluoromethyl)phenylboronic acid, pinacol ester;4-(Trifluoromethyl)aniline-2-boronic acid pinacol ester
• CAS NO: 1058062-64-8
• Molecular Formula: C₁₃H₁₇BF₃NO₂
• Molecular Weight: 287.0857896
• Mol File: 1058062-64-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine(1058062-64-8)
• EPA Substance Registry System: 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine(1058062-64-8)

Safety Data

• Hazardous Substances Data: 1058062-64-8(Hazardous Substances Data)

Usage

General Description

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzenamine is a chemical compound characterised by the inclusion of a boronic ester and an amine functional group on a benzene ring, which is in turn functionalised with a trifluoromethyl group. 2-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-_4-(trifluoroMethyl)_benzenaMine belongs to the class of organic compounds known as benzenamines, which are compounds containing a benzene ring linked to an amine moiety. It is typically used in palladium-catalyzed cross-coupling reactions, a key process in organic synthesis for constructing complex molecular structures. The exact properties such as boiling point, melting point, and solubility are largely dependent on the specific conditions and can be manipulated by altering these conditions as per requirement.

Upstream product

• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 
• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 455-14-1 4-trifluoromethylphenylamine 
• 175278-17-8 2-bromo-4-trifluoromethoxyaniline 

Downstream Products

• 1393606-40-0 1-methyl-2-(2-azido-5-trifluoromethylphenyl)pyridinium triflate 

Relevant articles and documents

Diastereoselective Oxidative CN/CO and CN/CN Bond Formation Tandems Initiated by Visible Light: Synthesis of Fused N-Arylindolines

The synthesis of fused N-arylindolines using visible light photoredox catalysis has been developed. We previously described that photogenerated amine radical cations generate substituted indoles through an intermediate benzylic carbocation. Herein, we expand the application of this chemistry by trapping the benzylic carbocation with tethered heteronucleophiles. The reactivity of the photogenerated benzylic carbocation is explored and applied to a range of substrates with various electronic characters and ring constraints. The method described provides C-2 and C-3 fused indolines bearing a tetrasubstituted carbon stereocenter with greater than 99:1 diastereoselectivity in moderate to good yields.

Achieving High Ortho Selectivity in Aniline C-H Borylations by Modifying Boron Substituents

High ortho selectivity for Ir-catalyzed C-H borylations (CHBs) of anilines results when B2eg2 (eg = ethylene glycolate) is used as the borylating reagent in lieu of B2pin2, which is known to give isomeric mixtures with anilines lacking a blocking group at the 4-position. With this modification, high selectivities and good yields are now possible for various anilines, including those with groups at the 2- and 3-positions. Experiments indicate that ArylN(H)Beg species are generated prior to CHB and support the improved ortho selectivity relative to B2pin2 reactions arising from smaller Beg ligands on the Ir catalyst. The lowest-energy transition states (TSs) from density functional theory computational analyses have N-H···O hydrogen-bonding interactions between PhN(H)Beg and O atoms in Beg ligands. Ir-catalyzed CHB of PhN(H)Me with B2eg2 is also highly ortho-selective. 1H NMR experiments show that N-borylation fully generates PhN(Me)Beg prior to CHB. The TS with the lowest Gibbs energy was the ortho TS, in which the Beg unit is oriented anti to the bipyridine ligand.

SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS

The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention. (I)