105836-96-2Relevant articles and documents
Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity
Yu, Wensheng,Coburn, Craig A.,Yang, De-Yi,Meinke, Peter T.,Wong, Michael,Rosenblum, Stuart B.,Chen, Kevin X.,Njoroge, George F.,Chen, Lei,Dwyer, Michael P.,Jiang, Yueheng,Nair, Anilkumar G.,Selyutin, Oleg,Tong, Ling,Zeng, Qingbei,Zhong, Bin,Ji, Tao,Hu, Bin,Agrawal, Sony,Xia, Ellen,Zhai, Ying,Liu, Rong,Kong, Rong,Ingravallo, Paul,Asante-Appiah, Ernest,Nomeir, Amin,Fells, James,Kozlowski, Joseph A.
, p. 3158 - 3162 (2016/06/13)
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed dose combination regimen for the treatment of HCV infection. Herein, we describe research efforts that led to the discovery of a series of fused tricyclic core containing HCV NS5A inhibitors such as 24, 39, 40, 43, and 44 which have pan-genotype activity and are orally bioavailable in the rat.
ORDER OF THE REPLACEMENT OF HYDROGEN BY HALOGEN IN THE HALOGENATION OF DIBENZO-p-DIOXIN AND ITS NITRO AND AMINO DERIVATIVES
Kuntsevich, A. D.,Golovkov, V. F.,Chernov, S. A.
, p. 1279 - 1286 (2007/10/02)
The order of the replacement of hydrogen by halogen in the bromination and chlorination of dibenzo-p-dioxin and its nitro and amino derivatives was examined with the purpose of determining the possibilities of the formation of highly toxic isomers of halogenated dibenzo-p-dioxins from precursors with a tricyclic structure of dibenzo-p-dioxin.A number of halogenated dibenzo-p-dioxins were synthesized, which illustrates the order of the replacement, and their physicochemical and spectral characteristics are given.
EFFECT OF THE CROWN ETHER 18-CROWN-6-ON CHLORINATION OF DIBENZO-p-DIOXIN AND ITS DERIVATIVES
Kuntsevich, A. D.,Golovkov, V. F.,Chernov, S. A.
, p. 245 - 247 (2007/10/02)
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