1058707-07-5Relevant articles and documents
Studies on the biosynthesis of bovilactone-4,4 and related fungal meroterpenoids
Lang, Martin,Muehlbauer, Andrea,Jaegers, Erhard,Steglich, Wolfgang
experimental part, p. 3544 - 3551 (2009/04/08)
The initial step in the biosynthesis of suillin (1), boviquinone-4 (2) and bovilactone-4,4 (3) in Suillus species is the geranylgeranylation of 3,4-dihydroxybenzoic acid at the 2-position. Feeding experiments with advanced precursors have identified boviquinone-4 and deacetylsuillin (9) as building blocks for the dilactone and catechol moieties, respectively, of bovilactone-4,4 (3). In order to explain the failure of boviquinone-4 (2) to incorporate side-chain-labelled deacetylsuillin (9#), an alternative sequence for the formation of 2 is proposed. During these experiments an interesting change in metabolism was noticed: after administration of larger quantities of aromatic carboxylic acids, the boviquinone-4 present in the fruit bodies disappeared and de novo synthesis of bovilactone-4,4 occurred. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.