105879-62-7

Basic information

• Product Name: 2(R)-(-)-4-chlorophenylpropanoic acid
• Synonyms: 2(R)-(-)-4-chlorophenylpropanoic acid
• CAS NO: 105879-62-7
• Molecular Weight: 184.622
• Mol File: 105879-62-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 297.4±15.0 °C(Predicted)
• Density: 1.263±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2(R)-(-)-4-chlorophenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-(-)-4-chlorophenylpropanoic acid(105879-62-7)
• EPA Substance Registry System: 2(R)-(-)-4-chlorophenylpropanoic acid(105879-62-7)

Safety Data

• Hazardous Substances Data: 105879-62-7(Hazardous Substances Data)

Usage

General Description

2(R)-(-)-4-chlorophenylpropanoic acid is a chemical compound with the molecular formula C9H9ClO2. It is an optically active form of the compound 4-chlorophenylpropanoic acid, and is specifically the (R)-enantiomer. 2(R)-(-)-4-chlorophenylpropanoic acid is a derivative of phenylpropanoic acid and contains a 4-chlorophenyl group. It is commonly used in the synthesis of pharmaceuticals and agrochemicals, and has potential applications in the field of medicine and drug development. The (R)-enantiomer has distinct stereochemical properties that make it useful for specific chemical reactions and processes. Overall, 2(R)-(-)-4-chlorophenylpropanoic acid is a valuable chemical compound with diverse potential applications and uses in various industries.

Upstream product

• 51747-43-4 2-(4-chlorophenyl)-acrylic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 64-18-6 formic acid 
• 465529-75-3 tert-butyl 2-(4-chlorophenyl)propanoate 
• 286964-62-3 2-(4-chlorophenyl)propanal 
• 1073-67-2 4-vinylbenzyl chloride 
• 1529-41-5 3-chloro-benzeneacetonitrile 
• 201230-82-2 carbon monoxide 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 
• 62784-66-1 bis(1-naphthyl)methanol 
• 2184-88-5 2-(4-chlorophenyl)propionitrile 
• 257298-95-6 (R)-2-(1-(4-chlorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 257298-99-0 2-[(R)-1-Chloro-2-(4-chloro-phenyl)-propyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 133809-10-6 (R)-(-)-2-(4'-chlorophenyl)propionamide 

Downstream Products

• 50415-70-8 (R)-2-(4-Chloro-phenyl)-propionic acid methyl ester 
• 27298-99-3 (R)-1-(4-chlorophenyl)ethylamine 
• 762300-25-4 (2R)-2-(4-chlorophenyl)-N-(3-{4-[5-(isobutyrylamino)-2-methylphenyl]-1-piperidinyl}propyl)propanamide 

Relevant articles and documents

KetoABNO/NOx Cocatalytic Aerobic Oxidation of Aldehydes to Carboxylic Acids and Access to α-Chiral Carboxylic Acids via Sequential Asymmetric Hydroformylation/Oxidation

A method for aerobic oxidation of aldehydes to carboxylic acids has been developed using organic nitroxyl and NOx cocatalysts. KetoABNO (9-azabicyclo[3.3.1]nonan-3-one N-oxyl) and NaNO2 were identified as the optimal nitroxyl and NOx sources, respectively. The mildness of the reaction conditions enables sequential asymmetric hydroformylation of alkenes/aerobic aldehyde oxidation to access α-chiral carboxylic acids without racemization. The scope, utility, and limitations of the oxidation method are further evaluated with a series of achiral aldehydes bearing diverse functional groups.

Iron-catalysed enantioselective Suzuki-Miyaura coupling of racemic alkyl bromides

The first iron-catalysed enantioselective Suzuki-Miyaura coupling reaction has been developed. In the presence of catalytic amounts of FeCl2 and (R,R)-QuinoxP?, lithium arylborates are cross-coupled with tert-butyl α-bromopropionate in an enantioconvergent manner, enabling facile access to various optically active α-arylpropionic acids including several nonsteroidal anti-inflammatory drugs (NSAIDs) of commercial importance. (R,R)-QuinoxP? is specifically able to induce chirality when compared to analogous P-chiral ligands that give racemic products, highlighting the critical importance of transmetalation in the present asymmetric cross-coupling system.

SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7'-diarylphosphino-1, 1'-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.