106017-08-7 Usage
Description
Rufloxacin hydrochloride is a fluoroquinolone antibiotic that is structurally and mechanistically related to temafloxacin and tosufloxacin. It is an orally active antibacterial agent known for its good tissue penetration and long-acting activity. Rufloxacin hydrochloride is particularly effective in inhibiting human organic cation transporter 1 (hOCT1) without affecting hOCT2 and hOCT3, which are also expressed in human embryonic kidney cells.
Uses
Used in Pharmaceutical Industry:
Rufloxacin hydrochloride is used as an antibiotic for the treatment of various bacterial infections, particularly respiratory and urinary tract infections, as well as chronic bacterial prostatitis. Its effectiveness in inhibiting hOCT1 makes it a valuable addition to the arsenal of antibiotics for combating resistant bacterial strains.
Used in Research and Development:
Rufloxacin hydrochloride is used as a research compound for studying the mechanisms of action and interactions of fluoroquinolone antibiotics with human organic cation transporters. This knowledge can contribute to the development of new drugs with improved efficacy and reduced side effects.
Brand Names:
Rufloxacin hydrochloride is available under the brand names Qari and Monos, which are marketed for the treatment of the aforementioned infections.
Originator
Mediolanum (Italy)
Check Digit Verification of cas no
The CAS Registry Mumber 106017-08-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,0,1 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106017-08:
(8*1)+(7*0)+(6*6)+(5*0)+(4*1)+(3*7)+(2*0)+(1*8)=77
77 % 10 = 7
So 106017-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H18FN3O3S.ClH/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24;/h8-9H,2-7H2,1H3,(H,23,24);1H
106017-08-7Relevant articles and documents
QUINOLINE DISULFIDES AS INTERMEDIATES
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, (2008/06/13)
A process for preparing rufloxacin using a compound of the formula I (I) as a starting material is described, where R is herein defined.
Quinilone disulfide as intermediates
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, (2008/06/13)
A process for preparing rufloxacin using a compound of the formula I STR1 as a starting material is described, where R is herein defined.
Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride
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, (2008/06/13)
Process for the preparation of 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride (Rufloxacin) by reaction of 2,3,5-trifluoro-4-(4-methyl-1-piperazinyl)benzoyl ethyl acetate with N,N-dimethylformamide dimethylacetal, followed by reaction with 2-aminoethanethiol, intramolecular cyclization by treatment with NaH, hydrolysis with H2 O and salification with HCl.