106020-70-6Relevant articles and documents
Aggregation of asphaltene model compounds using a porphyrin tethered to a carboxylic acid
Schulze, Matthias,Lechner, Marc P.,Stryker, Jeffrey M.,Tykwinski, Rik R.
, p. 6984 - 6991 (2015)
A Ni(ii) porphyrin functionalized with an alkyl carboxylic acid (3) has been synthesized to model the chemical behavior of the heaviest portion of petroleum, the asphaltenes. Specifically, porphyrin 3 is used in spectroscopic studies to probe aggregation with a second asphaltene model compound containing basic nitrogen (4), designed to mimic asphaltene behavior. NMR spectroscopy documents self-association of the porphyrin and aggregation with the second model compound in solution, and a Job's plot suggests a 1:2 stoichiometry for compounds 3 and 4. This journal is
Infinite Three-Dimensional Polymeric Metalloporphyrin Network via Six-Coordinate Zn(II) and Two Axial Oxygen Donors
Teo, Tang-Lin,Vetrichelvan, Muthalagu,Lai, Yee-Hing
, p. 4207 - 4210 (2003)
(Equation presented) An X-ray crystallographic study of zinc(II) 5,15-di-(2-methoxymethylphenyl)-porphyrin indicates that it forms a coordination polymer through ligation of the ether oxygen atoms on the porphyrin peripheries to the metal centers of two i
Quantitative structure-activity relationships of 2,4-diamino-5-(2-X- benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase
Selassie, Cynthia Dias,Gan, Wei-Xi,Kallander, Lara S.,Klein, Teri E.
, p. 4261 - 4272 (2007/10/03)
Quantitative structure-activity relationships (QSAR) have been formulated for a set of 15 2,4-diamino-5-(2-X-benzyl)pyrimidines versus dihydrofolate reductase from Lactobacillus casei and chicken liver. QSARs were also developed for comprehensive data sets containing mono-, di-, and trisubstituted benzyl derivatives. Particular emphasis was placed on the role played by ortho substituents in the overall binding process and subsequent inhibition of the catalytic process in both the prokaryotic and eucaryotic DHFRs. Comparisons between the two QSARs reveal subtle differences at specific positions which can be optimized to design more selective antibacterial agents.