1060616-79-6Relevant articles and documents
Preparation method for prasugrel hydrobromide
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Paragraph 0031; 0032; 0033; 0034; 0035; 0036; 0037-0048, (2017/04/29)
The invention relates to the technical field of medicine synthesis, and concretely relates to a preparation method for prasugrel hydrobromide. The preparation method for prasugrel hydrobromide comprises firstly dissolving or suspending prasugrel in an org
CRYSTALS OF PRASUGREL HYDROBROMATE
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Page/Page column 8, (2012/02/15)
The present application discloses crystals of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]p yridine hydrobromate, crystal compositions and pharmaceutical compositions comprising them and their use. The crystals of pra
METHOD OF PRODUCING HIGHLY PURE PRASUGREL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
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, (2011/06/16)
A method for the production of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate of formula (I) or its salts, characterized in that the compound of formula (III) in the form of a salt with an arene sulfonic acid is reacted with the compound of formula (XV), wherein Y means: chlorine, bromine, or an OR4 group, wherein R4 means an alkane sulfonic group or arene sulfonic group, in an organic solvent in the presence of an inorganic base or organic base, to give, after addition of an acetylating reagent and organic base to the reaction mixture, the compound of formula (I), which, after addition of a co-solvent, is crystallized from the reaction mixture, and the compound of formula (I) is optionally purified by crystallization and optionally converted to a salt by reaction with an organic or inorganic acid in a suitable solvent. (Formulae (I), (III), (XV)