1060805-66-4 Usage
Description
4-bromo-6-chloropicolinic acid is an organic compound characterized by the presence of a pyridine ring with a carboxylic acid group, a bromine atom at the 4-position, and a chlorine atom at the 6-position. This unique structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
4-bromo-6-chloropicolinic acid is used as a key intermediate in the synthesis of Naphthyridone p38 MAP kinase inhibitors for the treatment of rheumatoid arthritis and psoriasis. Its unique structure allows for the development of targeted therapies that can modulate the activity of the p38 MAP kinase pathway, which plays a crucial role in inflammatory processes and immune responses associated with these conditions.
In the synthesis of Naphthyridone p38 MAP kinase inhibitors, 4-bromo-6-chloropicolinic acid serves as a building block that can be further modified and functionalized to create potent and selective inhibitors. These inhibitors can effectively reduce inflammation and alleviate symptoms in patients suffering from rheumatoid arthritis and psoriasis, offering a promising therapeutic option for these debilitating diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1060805-66-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,0,8,0 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1060805-66:
(9*1)+(8*0)+(7*6)+(6*0)+(5*8)+(4*0)+(3*5)+(2*6)+(1*6)=124
124 % 10 = 4
So 1060805-66-4 is a valid CAS Registry Number.
1060805-66-4Relevant articles and documents
Preparation method of 4-bromo-6-chloropyridine-2-carboxylic acid
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Paragraph 0021-0057, (2020/12/29)
The invention relates to a preparation method of 4-bromo-6-chloropyridine-2-carboxylic acid. The preparation method of the 4-bromo-6-chloropyridine-2-carboxylic acid comprises the following steps: carrying out primary substitution reaction on 2,4-dihydroxy-6-methylpyridine and one of phosphorus oxybromide, phosphorus pentabromide or tetrabutylammonium bromide to generate 2-hydroxy-4-bromo-6-methylpyridine; carrying out secondary substitution reaction on the 2-hydroxy-4-bromine-6-methyl pyridine and phosphorus oxychloride or phosphorus pentachloride to generate 4-bromine-6-methyl-2-pyridine; according to the preparation method of the 4bromo 6chloropyridine 2carboxylic acid, the raw materials are cheap and easy to obtain, column chromatography purification is not needed in the reaction process, and the operation is simple and convenient.
