1060805-69-7

Basic information

• Product Name: 1-(4-bromopyridin-2-yl)ethanone
• Synonyms: 1-(4-bromopyridin-2-yl)ethanone;2-Acetyl-4-bromopyridine;1-(4-Bromo-2-pyridinyl)ethanone
• CAS NO: 1060805-69-7
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.03264
• Mol File: 1060805-69-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 267.3±25.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.534±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.06±0.10(Predicted)
• CAS DataBase Reference: 1-(4-bromopyridin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromopyridin-2-yl)ethanone(1060805-69-7)
• EPA Substance Registry System: 1-(4-bromopyridin-2-yl)ethanone(1060805-69-7)

Safety Data

• Hazardous Substances Data: 1060805-69-7(Hazardous Substances Data)

Usage

General Description

1-(4-bromopyridin-2-yl)ethanone is a chemical compound that belongs to the family of Pyridines and derivatives. Its systematic name is 1-(4-bromopyridin-2-yl)ethanone and has a molecular weight of 230.028 g/mol. The unique CAS registry number assigned to this chemical is 100331-89-3. Usually, it has the appearance of an off-white to beige crystalline powder. It's relatively stable when it comes to its physical and chemical attributes, but like all chemicals, it should be properly managed to avoid possible risks and hazards. It's used broadly in various scientific and industrial applications, particularly in the field of organic synthesis.

InChI:InChI=1S/C7H6BrNO/c1-5(10)7-4-6(8)2-3-9-7/h2-4H,1H3

Upstream product

• 62150-45-2 4-bromo-2-cyanopyridine 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 741709-58-0 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)ethan-1-one 
• 1404488-90-9 C₁₈H₁₇BrFN₃OS 
• 1404488-89-6 C₁₈H₁₈BrN₃O₂S 
• 1404488-83-0 C₁₈H₁₆BrN₃OS 
• 1404488-82-9 C₁₈H₁₇BrIN₃OS 
• 1404489-28-6 C₁₈H₁₆BrN₃OS 
• 1404489-19-5 C₂₄H₂₄BrN₃OS 

Relevant articles and documents

Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

As the number of individuals affected with Alzheimer's disease (AD) increases and the availability of drugs for AD treatment remains limited, the need to develop effective therapeutics for AD becomes more and more pressing. Strategies currently pursued include inhibiting acetylcholinesterase (AChE) and targeting amyloid-β (Aβ) peptides and metal-Aβ complexes. This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Aβ species, and inhibit AChE/BChE activity. Several chalcones were found to exhibit potent disaggregation of pre-formed N-biotinyl Aβ1-42 (bioAβ42) aggregates in vitro in the absence and presence of Cu2+/Zn2+, while others were effective at inhibiting the action of AChE.

COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.