106107-51-1

Basic information

• Product Name: Carbamic acid, (3,4-dimethoxyphenyl)-, ethyl ester
• CAS NO: 106107-51-1
• Molecular Formula: C11H15NO4
• Molecular Weight: 225.244
• Mol File: 106107-51-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (3,4-dimethoxyphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3,4-dimethoxyphenyl)-, ethyl ester(106107-51-1)
• EPA Substance Registry System: Carbamic acid, (3,4-dimethoxyphenyl)-, ethyl ester(106107-51-1)

Safety Data

• Hazardous Substances Data: 106107-51-1(Hazardous Substances Data)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 6315-89-5 3,4-dimethoxyaniline 
• 91-16-7 1,2-dimethoxybenzene 
• 817-87-8 ethyl azidocarbonate 
• 64-17-5 ethanol 
• 37527-66-5 3,4-dimethoxyphenylisocyanate 

Downstream Products

• 106107-49-7 ethyl 2-carboxy-3,4-dimethoxybenzenecarbamate 
• 6315-89-5 3,4-dimethoxyaniline 
• 13794-72-4 3H-6,7-dimethoxyquinazolin-4-one 

Relevant articles and documents

Substituted quinazolinones as kinase inhibitors endowed with anti-fibrotic properties

Some new 3-substituted quinazolinones were synthesized and evaluated as inhibitors of kinases involved in fibrogenic process. The compounds were tested against a panel of both tyrosine and serine-threonine kinases. The profile of selectivity of some representative compounds was investigated through molecular docking studies. The most interesting compounds were also evaluated in vitro as potential agents for the treatment of fibrotic diseases. Quinazolinone derivatives reduced proliferation and expression of genes involved in the fibrogenic process in hepatic stellate cells (HSCs) and intestinal subepithelial myofibroblasts (ISEMFs). Furthermore some compounds downregulated phosphorylation of p38MAPK. Our findings provide evidences that 3-substituted quinazolinones target multiple essential pathways of the fibrogenic process.

Alkyl 2-carboalkoxy-3,4-dialkoxybenzenecarbamates and process for their preparation

A process for the preparation of alkyl 2-carboxy-3,4-dialkoxybenzenecarbamates is described. The carbamates are useful intermediates in the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones. The diones are useful as cardiotonic agents.