1062233-83-3

Basic information

• Product Name: (S)-2-[((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid benzyl ester
• CAS NO: 1062233-83-3
• Molecular Weight: 482.577
• Mol File: 1062233-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid benzyl ester(1062233-83-3)
• EPA Substance Registry System: (S)-2-[((R)-1-tert-Butoxycarbonyl-2-phenyl-ethylcarbamoyl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid benzyl ester(1062233-83-3)

Safety Data

• Hazardous Substances Data: 1062233-83-3(Hazardous Substances Data)

Upstream product

• 16874-17-2 L-phenylalanine tert-butyl ester 
• 71461-30-8 (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 182967-41-5 (S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 182758-54-9 (R)-2-{2-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionyl)-pyrrolidin-2-yl]-2-oxo-acetylamino}-3-phenyl-propionic acid tert-butyl ester 

Relevant articles and documents

Poststatin, a new inhibitor of prolyl endopeptidase. VI. Endopeptidase inhibitory activity of poststatin analogues containing pyrrolidine ring

Several pyrrolidine-containing analogues of poststatin were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Replacement of the postine residue with 2-oxo-2-(2-pyrrolidinyl)acetic acid increased the selectivity and inhibitory activity against prolyl endopeptidase. Benzyloxycarbonyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl -D-phenylalanine was about 46 times as active to prolyl endopeptidase as natural poststatin.