1063-77-0

Basic information

• Product Name: Nomilin
• Synonyms: NOMILIN;1-(Acetyloxy)-1,2-dihydroobacunoic acid epislon-lactone;fromcitrusseeds;NOMILIN(RG);Oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione, 11-(acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyl-, (1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-;1-(Acetyloxy)-1,2-dihydroobacunoic acid ε-lactone;NOMILIN(P)(CALL);NOMILIN(P)
• CAS NO: 1063-77-0
• Molecular Formula: C28H34O9
• Molecular Weight: 514.56
• Product Categories: Limonoids (Citrus, Bitter Compounds);chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 1063-77-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 278-279°
• Boiling Point: 657.7 °C at 760 mmHg
• Flash Point: 351.6 °C
• Appearance: /
• Density: 1.33 g/cm³
• Vapor Pressure: 3.57E-17mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Nomilin(CAS DataBase Reference)
• NIST Chemistry Reference: Nomilin(1063-77-0)
• EPA Substance Registry System: Nomilin(1063-77-0)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 1063-77-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

Nomilin is a inducer of phase II detoxifying enzymes.

InChI:InChI=1/C28H34O9/c1-14(29)34-19-12-20(31)36-24(2,3)17-11-18(30)27(6)16(26(17,19)5)7-9-25(4)21(15-8-10-33-13-15)35-23(32)22-28(25,27)37-22/h8,10,13,16-17,19,21-22H,7,9,11-12H2,1-6H3/t16?,17?,19-,21+,22-,25+,26-,27+,28-/m1/s1

Downstream Products

• 751-03-1 Obacunon 

Related news

Nanoformulation and characterization of Nomilin (cas 1063-77-0) with different poly (lactic-co-glycolic acid) resomers and surfactants for the enhanced inhibition of α-amylase and angiotensin-converting-enzyme07/28/2019

To overcome the solubility and bioavailability challenges of nomilin, we have formulated and characterized a nanoparticle-based delivery system. Nomilin nanoparticles were prepared with poly (lactic-co-glycolic acid) (PLGA) resomers of different co-polymer composition and molecular weights with ...detailed

Citrus limonoid Nomilin (cas 1063-77-0) inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways07/27/2019

BackgroundAnimal experiment studies have revealed a positive association between intake of citrus fruits and bone health. Nomilin, a limonoid present in citrus fruits, is reported to have many biological activities in mammalian systems, but the mechanism of nomilin on bone metabolism regulation ...detailed

Citrus Nomilin (cas 1063-77-0) down-regulates TNF-α-induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IκB07/26/2019

Nomilin is a bitter compound present in citrus and has been demonstrated as useful for various disease preventions through anti-proliferative, anti-inflammatory, and pro-apoptotic activities. Although in vitro disease models have shown that certain limonoids in the p38 mitogen-activated protein ...detailed

Inhibition of Cytochrome P450 by Nomilin (cas 1063-77-0) and Obacunone and Potential Mechanism in Human Liver Microsomes07/25/2019

ObjectiveNomilin and obacunone are two important limonoids that are well known for their anticancer effect. Previous studies showed that limonoids had inhibitory effect on cytochrome P450 3A4 (CYP3A4). However these effects are inconclusive with regards to prediction of potential drug interactions.detailed

Temporal and spatial variations on accumulation of Nomilin (cas 1063-77-0) and limonin in the pummelos07/24/2019

Limonoids are the important secondary metabolites in the citrus. In this study, the accumulation of limonoids at different fruit developmental stages and distribution among different genotypes, tissues and developmental stages were investigated in 12 pummelo varieties. The large variations on li...detailed