1064001-49-5

Basic information

• Product Name: 1-(1-methylcycloprop-2-en-1-yl)-4-(trifluoromethyl)benzene
• Synonyms: 1-(1-methylcycloprop-2-en-1-yl)-4-(trifluoromethyl)benzene
• CAS NO: 1064001-49-5
• Molecular Weight: 198.188
• Mol File: 1064001-49-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(1-methylcycloprop-2-en-1-yl)-4-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-methylcycloprop-2-en-1-yl)-4-(trifluoromethyl)benzene(1064001-49-5)
• EPA Substance Registry System: 1-(1-methylcycloprop-2-en-1-yl)-4-(trifluoromethyl)benzene(1064001-49-5)

Safety Data

• Hazardous Substances Data: 1064001-49-5(Hazardous Substances Data)

Upstream product

• 1064000-94-7 1-(2,2-dibromo-1-methylcyclopropyl)-4-(trifluoromethyl)benzene 
• 55186-75-9 4-trifluoromethyl-α-methylstyrene 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 

Downstream Products

• 1356582-95-0 (4-chlorophenyl)((1R,2R)-2-methyl-(2-(4-trifluoromethyl)phenyl)cyclopropyl)methanone 

Relevant articles and documents

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

We report realization of the first enantioselective Cope-type hydroamination of oximes for asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene "hydronitronylation" process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions and displays broad scope and exceptionally high enantio- and diastereocontrol. Preliminary mechanistic studies corroborate a CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration process as the key C-N bond forming event. This conceptually novel reactivity enables the first example of highly enantioselective catalytic nitrone formation process and will likely spur further developments that may significantly expedite chiral nitrone synthesis.

Stereoselective Synthesis of Vinylcyclopropa[ b]indolines via a Rh-Migration Strategy

A mild rhodium catalytic system has been developed to synthesize vinylcyclopropa[b]indolines through cyclopropanation of indoles with vinyl carbenoids generated from ring opening of cyclopropenes in situ. By employing a Rh-migration strategy, the products can be obtained with good to excellent E:Z ratios (≤99:1) and complete diastereoselectivity (≤99:1). This method is easy, has a low catalyst loading, and works for a broad range of functionalities.

Improved preparative route toward 3-arylcyclopropenes

A convenient preparative protocol for the synthesis of various 3-arylcyclopropenes in a multigram scale is disclosed. Optimization of the reaction conditions and isolation procedures allowed for significant improvement of the chemical yields of these strained products. The described protocol was used for efficient preparation of a series of 3-methyl-3-arylcyclopropenes possessing different substituents in the aromatic ring. The effect of substitution in the aryl group on the stability of 3-arylcyclopropenes, as well as the corresponding precursors, is discussed.