1064710-43-5

Basic information

• Product Name: 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one
• Synonyms: 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one
• CAS NO: 1064710-43-5
• Molecular Weight: 342.348
• Mol File: 1064710-43-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one(1064710-43-5)
• EPA Substance Registry System: 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one(1064710-43-5)

Safety Data

• Hazardous Substances Data: 1064710-43-5(Hazardous Substances Data)

Upstream product

• 1064710-37-7 5,7-dimethoxy-2,2-dimethylbenzo[1,3]dioxin-4-one 
• 4302-52-7 4-ethynylveratrole 
• 1312774-65-4 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one 
• 1206482-93-0 4-(bromoethynyl)-1,2-dimethoxybenzene 

Downstream Products

• 23053-69-2 (Z)-2-(3,4-dimethoxybenzylidene)-4,6-dimethoxybenzofuran-3(2H)-one 
• 855-97-0 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one 

Relevant articles and documents

Facile access to sterically hindered aryl ketones via carbonylative cross-coupling: Application to the total synthesis of luteolin

A general and mild protocol for achieving the carbonylative cross-coupling of sterically hindered, ortho-disubstituted aryl ketones is reported. The commercially available PEPPSI-IPr catalyst is shown to efficiently promote the carbonylative cross-coupling of hindered ortho-disubstituted aryl iodides to give diaryl ketones; traditional phosphine catalysts are less effective. Carbonylative Suzuki-Miyaura cross-couplings provide a diverse array of biaryl ketones in good to excellent yields. The same catalyst is also shown to catalyze a carbonylative Negishi cross-coupling reaction, utilizing a variety of alkynyl-zinc reagents to give the corresponding alkynyl aryl ketones. Application of this new methodology to the synthesis of the natural product luteolin is reported.