1065544-11-7

Basic information

• Product Name: (4'-chloro-[1,1'-biphenyl]-2-yl)(phenyl)methanol
• Synonyms: (4'-chloro-[1,1'-biphenyl]-2-yl)(phenyl)methanol
• CAS NO: 1065544-11-7
• Molecular Weight: 294.78
• Mol File: 1065544-11-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4'-chloro-[1,1'-biphenyl]-2-yl)(phenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-chloro-[1,1'-biphenyl]-2-yl)(phenyl)methanol(1065544-11-7)
• EPA Substance Registry System: (4'-chloro-[1,1'-biphenyl]-2-yl)(phenyl)methanol(1065544-11-7)

Safety Data

• Hazardous Substances Data: 1065544-11-7(Hazardous Substances Data)

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 14774-78-8 4-chlorophenyl lithium 
• 100-52-7 benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 153850-83-0 4'-chlorobiphenyl-2-carboxaldehyde 
• 108-86-1 bromobenzene 

Downstream Products

• 1065544-69-5 2',2''-oxybis(phenylmethylene)bis(4-chlorobiphenyl) 
• 1065544-38-8 acetic acid (4'-chlorobiphenyl-2-yl)(phenyl)methyl ester 
• 1065544-70-8 2-chloro-9-phenyl-9H-fluorene 

Relevant articles and documents

Three-component coupling based on flash chemistry. Carbolithiation of benzyne with functionalized aryllithiums followed by reactions with electrophiles

A flow microreactor method for three-component coupling of benzyne was developed based on flash chemistry. o-Bromophenyllithium generated from 1-bromo-2-iodobenzene and a functionalized aryllithium generated from the corresponding aryl halide were mixed at -70 °C. In the subsequent reactor o-bromophenyllithium is decomposed to generate benzyne without affecting the functionalized aryllithium at -30 °C, and carbolithiation of benzyne with the aryllithium took place spontaneously. The resulting functionalized biaryllithium was reacted with an electrophile in the subsequent reactor to give the corresponding three-component coupling product. The precise optimization of reaction conditions using the temperature-residence time mapping is responsible for the success of the present transformation. The present method has been successfully applied to the synthesis of boscalid.

A general and efficient synthesis of substituted fluorenes and heterocycle-fused indenes containing thiophene or indole rings utilizing a Suzuki-Miyaura coupling and acid-catalyzed Friedel-Crafts reactions as key steps

A general and efficient synthesis of fluorenes or heterocycle-fused indenes including 3-thia-cyclopenta[a]indenes, 9-thia-indeno[1,2-a]indenes, 5,6-dihydroindeno[2,1-b]indoles has been developed. This methodology is realized by a multistep protocol involv