106881-41-8 Usage
Description
4,5-Desisopropylidene Topiramate is a metabolite of Topiramate, which is an off-white solid. It is a chemical compound derived from the parent drug Topiramate, which is primarily used as an anticonvulsant and for the prophylaxis of migraine headaches. The compound is characterized by its off-white solid appearance and is a result of the metabolism of Topiramate in the body.
Uses
Used in Pharmaceutical Industry:
4,5-Desisopropylidene Topiramate is used as an intermediate in the synthesis of Topiramate for its various applications in the treatment of epilepsy and migraines. As a metabolite, it plays a role in the drug's overall efficacy and pharmacokinetics, contributing to the management of these conditions.
Used in Research and Development:
In the field of pharmaceutical research and development, 4,5-Desisopropylidene Topiramate serves as a valuable compound for studying the metabolic pathways of Topiramate and understanding its interactions with the human body. This knowledge can be applied to improve the drug's formulation, delivery, and overall effectiveness in treating epilepsy and migraines.
Used in Quality Control and Analysis:
4,5-Desisopropylidene Topiramate is utilized in the quality control and analysis of Topiramate-containing pharmaceutical products. As a metabolite, it can be used to monitor the purity, potency, and stability of Topiramate in various drug formulations, ensuring the safety and efficacy of the medication for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 106881-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,8,8 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 106881-41:
(8*1)+(7*0)+(6*6)+(5*8)+(4*8)+(3*1)+(2*4)+(1*1)=128
128 % 10 = 8
So 106881-41-8 is a valid CAS Registry Number.
106881-41-8Relevant articles and documents
Anticonvulsant O-Alkyl Sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose Sulfamate and Related Compounds.
Maryanoff, Bruce E.,Nortey, Samuel O.,Gardocki, Joseph F.,Shank, Richard P.,Dodgson, Susanna P.
, p. 880 - 887 (1987)
Novel sugar sulfamate 1 (McN-4853, topiramate) has been found to exhibit potent anticonvulsant activity analogous to that of phenytoin.In the maximal electroshock seizure test, orally at 2 h in mice, 1 had an ED50 of 39 mg/kg.Orally, 1 had a duration of action in excess of 8 h.Other aspects of the pharmacology of 1, as well as neurochemistry and carbonic anhydrase inhibition, are discussed.The conformational behavior of 1 in solution and in the solid state are discussed.A series of analogues of 1 were synthesized and examined for anticonvulsant properties.
