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106900-12-3

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106900-12-3 Usage

Description

Loperamide, also known as Loperamide oxide (LOPOX), is a prodrug that is reduced to its active form, Loperamide (LOP), when administered intraluminally. It is a white or almost white powder with slightly hygroscopic properties. Loperamide is known for its antisecretory potency, making it a pharmaceutical candidate for various applications.

Uses

Used in Pharmaceutical Industry:
Loperamide is used as an antisecretory agent for treating diarrhea and other gastrointestinal disorders. It is effective in reducing the secretion of fluids in the jejunum and colon, providing relief from symptoms associated with these conditions.
Used in Research and Development:
Loperamide oxide (LOPOX) serves as a prodrug for Loperamide (LOP) in research and development, allowing scientists to study its reduction process and antisecretory potency. This knowledge can be applied to develop new formulations and delivery methods for Loperamide, potentially improving its efficacy and safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 106900-12-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,9,0 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 106900-12:
(8*1)+(7*0)+(6*6)+(5*9)+(4*0)+(3*0)+(2*1)+(1*2)=93
93 % 10 = 3
So 106900-12-3 is a valid CAS Registry Number.
InChI:InChI=1/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3

106900-12-3 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000341)  Loperamide oxide monohydrate  European Pharmacopoeia (EP) Reference Standard

  • 106900-12-3

  • Y0000341

  • 1,880.19CNY

  • Detail
  • USP

  • (1370065)  Loperamide Related Compound F  United States Pharmacopeia (USP) Reference Standard

  • 106900-12-3

  • 1370065-25MG

  • 14,500.98CNY

  • Detail

106900-12-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

1.2 Other means of identification

Product number -
Other names Loperamide N-oxide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106900-12-3 SDS

106900-12-3Upstream product

106900-12-3Downstream Products

106900-12-3Related news

Investigation of the effects of axitinib on the pharmacokinetics of Loperamide (cas 106900-12-3) and its main metabolite N-demethylated Loperamide (cas 106900-12-3) in rats by UPLC-MS/MS08/05/2019

The epidemic of loperamide abuse and misuse in the patients for the alternative to opioids has become an increasing worldwide concern and has led to considerations about the potential for drug-drug interactions between loperamide and other combined drugs, especially inhibitors of cytochrome P450...detailed

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