1069106-59-7Relevant articles and documents
Nucleophilic reaction of cyclopentylamine on phthalimide derivatives: Synthesis and antinociceptive activity of products
Okunrobo, Lucky O.,Chukwuka, Madu J.,Nzenwa, Chisom P.
, p. 365 - 368 (2008/09/20)
The reaction of cyclopentylamine with N-prop-2-ynylphthalimde 1a and 4-phthalimidobutyric acid 1b was carried out in dimethylformamide at room temperature to afford benzamido-N-prop-2-ynyl-N-cyclopentyl -carboxamide (3) and benzamido-N,N-bis (cyclopentyl)-carboxamide (4), respectively. IR, NMR, and microanalyses were used to unequivocally characterize the compounds obtained. The new compounds were evaluated pharmacologically for their in vivo antinociceptive activity using acetic acid-induced writhing assay and compound 3 had significant activity (70%) comparable to indomethacin (71%) but better than acetylsalicylic acid (59%), however, compound 4 had lower activity (29%). The effects were dose-dependent.