1070781-84-8

Basic information

• Product Name: (2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one
• Synonyms: (2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one
• CAS NO: 1070781-84-8
• Molecular Weight: 380.441
• Mol File: 1070781-84-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one(1070781-84-8)
• EPA Substance Registry System: (2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one(1070781-84-8)

Safety Data

• Hazardous Substances Data: 1070781-84-8(Hazardous Substances Data)

Upstream product

• 1070782-29-4 2,4-diallyloxy-6-methoxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 56121-44-9 (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 

Relevant articles and documents

COMPOUNDS, THEIR SYNTHESES, AND THEIR USES

Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2′,4′-diallyloxy- 6′-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 μM, four of which exhibited a selectivity index greater than 12.