1072032-75-7

Basic information

• Product Name: (1S,3aS,41R,4a1S,5R,10aS,12aS)-8-(benzyloxyimino)-1-(furan-3-yl)-4a1,7,7,10a,12a-pentamethyl-3-oxo-1,3.3a,4a1,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
• Synonyms: (1S,3aS,41R,4a1S,5R,10aS,12aS)-8-(benzyloxyimino)-1-(furan-3-yl)-4a1,7,7,10a,12a-pentamethyl-3-oxo-1,3.3a,4a1,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
• CAS NO: 1072032-75-7
• Molecular Weight: 587.713
• Mol File: 1072032-75-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,3aS,41R,4a1S,5R,10aS,12aS)-8-(benzyloxyimino)-1-(furan-3-yl)-4a1,7,7,10a,12a-pentamethyl-3-oxo-1,3.3a,4a1,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3aS,41R,4a1S,5R,10aS,12aS)-8-(benzyloxyimino)-1-(furan-3-yl)-4a1,7,7,10a,12a-pentamethyl-3-oxo-1,3.3a,4a1,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate(1072032-75-7)
• EPA Substance Registry System: (1S,3aS,41R,4a1S,5R,10aS,12aS)-8-(benzyloxyimino)-1-(furan-3-yl)-4a1,7,7,10a,12a-pentamethyl-3-oxo-1,3.3a,4a1,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate(1072032-75-7)

Safety Data

• Hazardous Substances Data: 1072032-75-7(Hazardous Substances Data)

Upstream product

• 2753-30-2 gedunin 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 

Relevant articles and documents

Gedunin, a novel Hsp90 inhibitor: Semisynthesis of derivatives and preliminary structure-activity relationships

Gedunin (1), a tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors. The mechanism of action by which gedunin induces client protein degradation remains undetermined, however, prior studies have demonstrated that it does not bind competitively versus ATP. In an effort to further probe the mechanism of action, 19 semisynthetic derivatives of gedunin were prepared and their antiproliferative activity against MCF-7 and SkBr3 breast cancer cells determined. Although no compound was found to exhibit antiproliferative activity more effective than the natural product, functionalities critical for antiproliferative activity have been identified.