Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1072946-50-9

1072946-50-9

Post Buying Request

1072946-50-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1072946-50-9 Usage

General Description

6-Chloro-2-methoxypyridine-3-boronic acid is a specialized chemical compound extensively used in the pharmaceutical and chemical industry. 6-Chloro-2-methoxypyridine-3-boronic acid, with a relatively complex structure, is known for its significant use in the organic synthesis of various chemical reactions. Structurally, it consists of a 6-chloro-2-methoxypyridine ring with a boronic acid group at the 3-position. Its molecular formula is C?H?BClNO?, and it often appears as an off-white to light yellow solid. It is also frequently used in Suzuki coupling reactions, which are very powerful for forming carbon-carbon bonds. Further, it is known for its high reactivity and versatile applications in medicinal chemistry and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 1072946-50-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,9,4 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1072946-50:
(9*1)+(8*0)+(7*7)+(6*2)+(5*9)+(4*4)+(3*6)+(2*5)+(1*0)=159
159 % 10 = 9
So 1072946-50-9 is a valid CAS Registry Number.

1072946-50-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Aldrich

  • (SYX00002)  6-Chloro-2-methoxypyridine-3-boronic acid  AldrichCPR

  • 1072946-50-9

  • SYX00002-1G

  • 773.37CNY

  • Detail

1072946-50-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (6-Chloro-2-methoxypyridin-3-yl)boronic acid

1.2 Other means of identification

Product number -
Other names (6-chloro-2-methoxypyridin-3-yl)boronic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1072946-50-9 SDS

1072946-50-9Synthetic route

2,5-dibromo-3-nitro-pyridine
15862-37-0

2,5-dibromo-3-nitro-pyridine

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

5-bromo-6’-chloro-2’-methoxy-3-nitro-2,3’-bipyridine

Conditions
ConditionsYield
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran at 80℃; Suzuki Coupling; Inert atmosphere; Sealed tube;78%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-2-methoxypyridine
17228-64-7

6-chloro-2-methoxypyridine

Conditions
ConditionsYield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water In toluene at 90℃; for 3h; Microwave irradiation; Green chemistry;72%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine
1562338-65-1

6-chloro-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(6-chloro-2-methoxypyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 90℃; for 16h;55%
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-chloro-3-iodo-2-methoxypyridine
1261769-34-9

6-chloro-3-iodo-2-methoxypyridine

Conditions
ConditionsYield
With N-iodo-succinimide at 90℃; for 0.0833333h; Microwave irradiation;51%
(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water for 1.16667h;
Stage #1: (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium acetate In 1,2-dimethoxyethane; water for 1.16667h; Inert atmosphere;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-chloro-6-methoxypyridine-5-d

2-chloro-6-methoxypyridine-5-d

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water / toluene / 3 h / 90 °C / Microwave irradiation; Green chemistry
2: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); water-d2 / toluene; tetrahydrofuran / 2 h / 90 °C / Microwave irradiation
View Scheme
(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester
1007882-59-8

(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C18H23ClN4O3
1255936-29-8

C18H23ClN4O3

Conditions
ConditionsYield
Stage #1: (S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester With palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,2-dimethoxyethane at 100℃; for 0.0833333h; Inert atmosphere;
Stage #2: (6-chloro-2-methoxypyridin-3-yl)boronic acid With potassium carbonate In 1,2-dimethoxyethane; water at 100℃; for 1.16667h;
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one

Conditions
ConditionsYield
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
With pyridine; copper diacetate In acetonitrile for 6h; Molecular sieve; Reflux;0.075 g
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

1-(2-{[1-(6-chloro-2-methoxypyridin-3-yl)-1H-pyrazol-3-yl]oxymethyl}-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-thione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: Lawessons reagent / toluene / 5 h / Reflux
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

1-(2-[{(1H-pyrazol-3-yl)}oxymethyl]-3-methylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

3-[(2-amino-6-methylphenyl)methyloxy]-1-(2-methoxy-6-chloropyridin-3-yl)pyrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 6 h / Molecular sieve; Reflux
2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 6 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

1-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}ethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

2-{8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube
5.2: 1.5 h
6.1: cerium(III) chloride / tetrahydrofuran / 0.02 h / 20 °C
6.2: 0.17 h
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

8-[(S)-(3-fluoropyridin-2-yl)(oxan-4-yl)methyl]-13-methoxy-N-methyl-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-N-[2-(methylamino)ethyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
5: triethylamine / 0.5 h / Microwave irradiation
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-methanesulfonyl-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: copper(II) bis(trifluoromethanesulfonate); N,N`-dimethylethylenediamine / dimethyl sulfoxide / 4 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-(4,4-difluoropiperidin-l-yl)-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
5: palladium diacetate; ruphos; sodium t-butanolate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

A

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(R)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

B

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

(S)-2-{8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaen-11-yl}propan-2-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
6.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

3-bromo-7-chloro-9-methoxy-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

(S)-3-bromo-7-chloro-9-methoxy-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrrolo[3,2-b:4,5-c’]dipyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-oxan-4-yl(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: triphenylphosphine; triethylamine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C
4: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

11-chloro-8-[(4,4-difluorocyclohexyl)(phenyl)methyl]-13-methoxy-5-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

C30H27(2)H3F2N6O2

C30H27(2)H3F2N6O2

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 80 °C / Inert atmosphere; Sealed tube
2.1: 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-benzene / 1 h / 150 °C / Inert atmosphere
3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed tube
4.1: di-isopropyl azodicarboxylate; triphenylphosphine; triethylamine / dichloromethane / 0 - 20 °C
5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5.2: 2 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

6-[2-methoxy-6-(1H-pyrazol-4-yl)pyridin-3-yl]-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

6-(2-methoxy-6-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)pyridin-3-yl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

3-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)pyridazin-3-yl)-6-(1H-pyrazol-4-yl)pyridin-2-ol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 16 h / 90 °C
3: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C
View Scheme
(6-chloro-2-methoxypyridin-3-yl)boronic acid
1072946-50-9

(6-chloro-2-methoxypyridin-3-yl)boronic acid

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 4-bromo-2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-1H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

(S)-tert-butyl 2-(1-((tert-butoxycarbonyl)amino)-7-(oxazol-2-yl)-7-oxoheptyl)-4-(6-chloro-2-methoxypyridin-3-yl)-l H-imidazole-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In tetrahydrofuran; water at 20 - 60℃; for 2h;

1072946-50-9Upstream product

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1072946-50-9